The Water Drinking Test

Ocular hypertension and systemic responses to the water-drinking test.

“…A. Siddiqui, and H. C. Donovan Discussion In these experiments comparisons involving the normal group are speculative in view of its size and the age differences involved, but even so group allocation using discriminant analysis-which for retrospective allocation clearly involves a deal of circular argument-is surprisingly successful, and the differences involved are not necessarily simply age-related artefacts. The persistent group differences involving plasma potassium levels are particularly interesting, and we have since found that Spaeth (1967) and Iverson and Brown (1967) commented on the erratic responses of plasma potassium after water loading in studies of glaucoma suspects and patients with open-angle glaucoma. This phenomenon may be an important aetiological pointer and from contemporary studies adrenocortical and/or renal associations are obvious possibilities.…”

“…Winder et al, 1974). Detectable osmolar responses to water loading continue long after 60 minutes (Spaeth, 1967;Iverson and Brown, 1967), but the substantial challenge is over by that time. Systemic differences in the water-load response profiles are therefore present, and drinking habits may indeed be important in terms of the ocular osmolar stress involved.…”

“…We regard this lack of difference between the ocular hypertension and chronic simple glaucoma groups as an inconclusive result, as the true categories of patients in the glaucoma suspect group are uncertain, age ranges are not stated, and these earlier data are unusual in some respects. Very little variation was found in the initial osmolality values between subjects and between groups, relationships between the ocular pressures and osmolar responses were not close (comment by Spaeth, 1967), and subjects in whom the peak osmolal response did not exceed 6 milliosmoles were excluded. This recalculation has none the less been an instructive exercise, and there is a lack of studies published in sufficient detail to allow intergroup comparisons as above, although the relevant data are no doubt variously held.…”

Ocular hypertension and systemic responses to the water-drinking test.

“…A. Siddiqui, and H. C. Donovan Discussion In these experiments comparisons involving the normal group are speculative in view of its size and the age differences involved, but even so group allocation using discriminant analysis-which for retrospective allocation clearly involves a deal of circular argument-is surprisingly successful, and the differences involved are not necessarily simply age-related artefacts. The persistent group differences involving plasma potassium levels are particularly interesting, and we have since found that Spaeth (1967) and Iverson and Brown (1967) commented on the erratic responses of plasma potassium after water loading in studies of glaucoma suspects and patients with open-angle glaucoma. This phenomenon may be an important aetiological pointer and from contemporary studies adrenocortical and/or renal associations are obvious possibilities.…”

“…Winder et al, 1974). Detectable osmolar responses to water loading continue long after 60 minutes (Spaeth, 1967;Iverson and Brown, 1967), but the substantial challenge is over by that time. Systemic differences in the water-load response profiles are therefore present, and drinking habits may indeed be important in terms of the ocular osmolar stress involved.…”

“…We regard this lack of difference between the ocular hypertension and chronic simple glaucoma groups as an inconclusive result, as the true categories of patients in the glaucoma suspect group are uncertain, age ranges are not stated, and these earlier data are unusual in some respects. Very little variation was found in the initial osmolality values between subjects and between groups, relationships between the ocular pressures and osmolar responses were not close (comment by Spaeth, 1967), and subjects in whom the peak osmolal response did not exceed 6 milliosmoles were excluded. This recalculation has none the less been an instructive exercise, and there is a lack of studies published in sufficient detail to allow intergroup comparisons as above, although the relevant data are no doubt variously held.…”

Assessment of Choroidal Thickness and Volume during the Water Drinking Test by Swept-Source Optical Coherence Tomography

“…11 In the present study, we used SS-OCT with a novel automated segmentation software to measure choroidal thickness and volume before and after the water-drinking test in healthy individuals. We showed that there is a consistent and statistically significant increase of peripapillary and macular choroidal thickness and volume after the WDT.…”

A Standard Water Provocative Test for Dogs Anaesthetized with Acepromazine‐Ketamine

“…As several authors have previously reported, ingestion of a measured volume of water produces plasma dilution that, together with other factors, leads to an increase in the formation of aqueous humour which, in turn, raises intraocular pressure (CASEY, 1965;GALIN et al, 1965;GELAIT et al, 1976;SPAETH, 1967). This aqueous humour is not drained adequately in pre-glaucomatous eyes, so the IOP increases substantially and remains high for a long time.…”

Ocular hypertension and systemic responses to the water-drinking test.

“…A. Siddiqui, and H. C. Donovan Discussion In these experiments comparisons involving the normal group are speculative in view of its size and the age differences involved, but even so group allocation using discriminant analysis-which for retrospective allocation clearly involves a deal of circular argument-is surprisingly successful, and the differences involved are not necessarily simply age-related artefacts. The persistent group differences involving plasma potassium levels are particularly interesting, and we have since found that Spaeth (1967) and Iverson and Brown (1967) commented on the erratic responses of plasma potassium after water loading in studies of glaucoma suspects and patients with open-angle glaucoma. This phenomenon may be an important aetiological pointer and from contemporary studies adrenocortical and/or renal associations are obvious possibilities.…”

“…Winder et al, 1974). Detectable osmolar responses to water loading continue long after 60 minutes (Spaeth, 1967;Iverson and Brown, 1967), but the substantial challenge is over by that time. Systemic differences in the water-load response profiles are therefore present, and drinking habits may indeed be important in terms of the ocular osmolar stress involved.…”

“…We regard this lack of difference between the ocular hypertension and chronic simple glaucoma groups as an inconclusive result, as the true categories of patients in the glaucoma suspect group are uncertain, age ranges are not stated, and these earlier data are unusual in some respects. Very little variation was found in the initial osmolality values between subjects and between groups, relationships between the ocular pressures and osmolar responses were not close (comment by Spaeth, 1967), and subjects in whom the peak osmolal response did not exceed 6 milliosmoles were excluded. This recalculation has none the less been an instructive exercise, and there is a lack of studies published in sufficient detail to allow intergroup comparisons as above, although the relevant data are no doubt variously held.…”

Assessment of Choroidal Thickness and Volume during the Water Drinking Test by Swept-Source Optical Coherence Tomography

“…11 In the present study, we used SS-OCT with a novel automated segmentation software to measure choroidal thickness and volume before and after the water-drinking test in healthy individuals. We showed that there is a consistent and statistically significant increase of peripapillary and macular choroidal thickness and volume after the WDT.…”

A Standard Water Provocative Test for Dogs Anaesthetized with Acepromazine‐Ketamine

“…As several authors have previously reported, ingestion of a measured volume of water produces plasma dilution that, together with other factors, leads to an increase in the formation of aqueous humour which, in turn, raises intraocular pressure (CASEY, 1965;GALIN et al, 1965;GELAIT et al, 1976;SPAETH, 1967). This aqueous humour is not drained adequately in pre-glaucomatous eyes, so the IOP increases substantially and remains high for a long time.…”

Ocular hypertension and systemic responses to the water-drinking test.

“…A. Siddiqui, and H. C. Donovan Discussion In these experiments comparisons involving the normal group are speculative in view of its size and the age differences involved, but even so group allocation using discriminant analysis-which for retrospective allocation clearly involves a deal of circular argument-is surprisingly successful, and the differences involved are not necessarily simply age-related artefacts. The persistent group differences involving plasma potassium levels are particularly interesting, and we have since found that Spaeth (1967) and Iverson and Brown (1967) commented on the erratic responses of plasma potassium after water loading in studies of glaucoma suspects and patients with open-angle glaucoma. This phenomenon may be an important aetiological pointer and from contemporary studies adrenocortical and/or renal associations are obvious possibilities.…”

“…Winder et al, 1974). Detectable osmolar responses to water loading continue long after 60 minutes (Spaeth, 1967;Iverson and Brown, 1967), but the substantial challenge is over by that time. Systemic differences in the water-load response profiles are therefore present, and drinking habits may indeed be important in terms of the ocular osmolar stress involved.…”

“…We regard this lack of difference between the ocular hypertension and chronic simple glaucoma groups as an inconclusive result, as the true categories of patients in the glaucoma suspect group are uncertain, age ranges are not stated, and these earlier data are unusual in some respects. Very little variation was found in the initial osmolality values between subjects and between groups, relationships between the ocular pressures and osmolar responses were not close (comment by Spaeth, 1967), and subjects in whom the peak osmolal response did not exceed 6 milliosmoles were excluded. This recalculation has none the less been an instructive exercise, and there is a lack of studies published in sufficient detail to allow intergroup comparisons as above, although the relevant data are no doubt variously held.…”

Assessment of Choroidal Thickness and Volume during the Water Drinking Test by Swept-Source Optical Coherence Tomography

“…11 In the present study, we used SS-OCT with a novel automated segmentation software to measure choroidal thickness and volume before and after the water-drinking test in healthy individuals. We showed that there is a consistent and statistically significant increase of peripapillary and macular choroidal thickness and volume after the WDT.…”

A Standard Water Provocative Test for Dogs Anaesthetized with Acepromazine‐Ketamine

“…As several authors have previously reported, ingestion of a measured volume of water produces plasma dilution that, together with other factors, leads to an increase in the formation of aqueous humour which, in turn, raises intraocular pressure (CASEY, 1965;GALIN et al, 1965;GELAIT et al, 1976;SPAETH, 1967). This aqueous humour is not drained adequately in pre-glaucomatous eyes, so the IOP increases substantially and remains high for a long time.…”