The vulvovaginal-gingival syndrome of lichen planus. The clinical characteristics of 22 patients

Eisen, Drore

doi:10.1001/archderm.130.11.1379

Cited by 40 publications

(49 citation statements)

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“…It is the first prospective study to document the response of the clinical signs and symptoms of ELPV to treatment. This study confirms that ELPV is a disease of perimenopausal and postmenopausal women, with a mean age at onset of symptoms of 57 years, similar to findings of other series (age range, 49-52 years 4,[7][8][9] ). In contrast, extragenital cutaneous LP has a younger age at onset, usually occurring in the fourth to sixth decades of life.…”

Section: Commentsupporting

confidence: 91%

“…Some previous reports have suggested that the prognosis for ELPV is poor with difficulties in treatment, 1,4 but this cohort showed a good response to treatment. Vulval symptoms improved in three quarters (75%) of the women with time and treatment and in approximately half (54%) who had become asymptomatic.…”

Section: Commentcontrasting

confidence: 49%

“…8 The overall prevalence of vaginal disease (26%, but 58% of the 52 examined) is lower in this study than in some other series (58% 1 -100% 25 ); however, patients in these series were selected to illustrate the vulvovaginal-gingival syndrome and so are biased in favor of vaginal disease. 4,25 One of the difficulties with the present study is that it proved impossible to examine the vagina adequately in all patients because of pain or narrowing of the introitus. Therefore it is likely that some cases of vaginal disease were missed.…”

Section: Commentmentioning

confidence: 91%

“…3 To date, there have been very few studies of vulval LP, and all have been retrospective. One of the largest and most complete clinical studies is the series by Eisen 4 of 22 female patients with the vulvovaginal-gingival syndrome. Information on outcome and likely response to treatment is not available; thus, it has been difficult to give advice to patients with ELPV as to prognosis, likely response to treatment, and risk of vulval malignancy.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Influence of Treatment of Erosive Lichen Planus of the Vulva on Its Prognosis

Cooper¹,

Wojnarowska²

2006

Arch Dermatol

142

137

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Section: Commentsupporting

confidence: 91%

Section: Commentcontrasting

confidence: 49%

Section: Commentmentioning

confidence: 91%

mentioning

confidence: 99%

See 2 more Smart Citations

Influence of Treatment of Erosive Lichen Planus of the Vulva on Its Prognosis

Cooper¹,

Wojnarowska²

2006

Arch Dermatol

142

137

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“…[1][2][3][4] Treatment is very difficult. Vulvovaginal LP is perceived as poorly responsive to topical corticosteroids.…”

mentioning

confidence: 99%

Vulvovaginal Lichen Planus Treatment: A Survey of Current Practices

Cooper¹,

Haefner²,

Abrahams‐Gessel³

et al. 2008

Arch Dermatol

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Recalcitrant Symptomatic Vulvar Lichen Planus

Byrd¹,

Davis²,

Rogers³

2004

Arch Dermatol

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Background: Topical tacrolimus has been reported to be an effective treatment for genital lichen planus in small case series. We retrospectively reviewed the medical records of 16 patients with symptomatic vulvar lichen planus who received treatment with tacrolimus ointment. Observations: All patients had symptomatic vulvar lichen planus recalcitrant to other treatments. Of 16 patients, 15 (94%) experienced a symptomatic response to tacrolimus treatment within 3 months (mean, 4.2 weeks) and had a partial or complete resolution of the lesions. Six patients (38%) reported mild adverse effects, including irritation, burning, and tingling. With continued use of the medication, these adverse effects resolved. When patients stopped treatment, lichen planus returned in 10 (83%) of 12 patients within 6 months after discontinuation of therapy (median, 1 week; range, 0.3-24 weeks), but in 6 patients the lesions were less severe than the lesions before treatment; all 10 patients resumed use of topical tacrolimus. Conclusions: In this retrospective series of 16 women with vulvar lichen planus, topical tacrolimus therapy effectively controlled symptoms and improved lesions in all but 1 patient. The effect may be temporary, requiring continued use of tacrolimus, which appears to be safe and effective in controlling disease activity.

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The vulvovaginal-gingival syndrome of lichen planus. The clinical characteristics of 22 patients

Cited by 40 publications

References 0 publications

Influence of Treatment of Erosive Lichen Planus of the Vulva on Its Prognosis

Influence of Treatment of Erosive Lichen Planus of the Vulva on Its Prognosis

Vulvovaginal Lichen Planus Treatment: A Survey of Current Practices

Recalcitrant Symptomatic Vulvar Lichen Planus

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