The Volatile Oil Composition of Fresh and Air-Dried Buds of <i>Cannabis sativa</i>

Ross, Samir A.; ElSohly, Mahmoud A.

doi:10.1021/np960004a

Cited by 149 publications

(130 citation statements)

References 13 publications

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“…Hashish looks like a hard yellowish-brownish paste that becomes malleable upon heating and different samples can present a high variety in terms of color, density, content of the active principles and flavor [1]. Besides the biologically active cannabinoids, more than 90 phytocannabinoids have been isolated from Cannabis and its essential oil is a complex mixture containing also monoterpenoids and sesquiterpenoids [5][6][7][8], giving it the typical organoleptic properties. The volatiles constituents of Cannabis have been extensively studied [9] because they represent a potential for chemically fingerprinting different cultivars [10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Volatile Components of Cannabis Preparations by Solid-Phase Microextraction Coupled to Headspace-Gas Chromatography with Mass Detector (SPME-HSGC/MS)

Arnoldi¹,

Roda²,

Casagni³

et al. 2017

J Chromatogr Sep Tech

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Section: Introductionmentioning

confidence: 99%

Characterization of the Volatile Components of Cannabis Preparations by Solid-Phase Microextraction Coupled to Headspace-Gas Chromatography with Mass Detector (SPME-HSGC/MS)

Arnoldi¹,

Roda²,

Casagni³

et al. 2017

J Chromatogr Sep Tech

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“…Compound identification was based on mass spectra, retention times compared with authentic standards and retention indexes reported in literature. 25,26) Mono-terpenoids were quantified using a linear calibration curve for myrcene (yϭ 6945.1x; r 2 ϭ0.997), sesquiterpenoids with a-humulene (yϭ 7529.5x; r 2 ϭ0.998), and cannabinoids with D…”

mentioning

confidence: 99%

Cannabinoid Receptor 1 Binding Activity and Quantitative Analysis of Cannabis sativa L. Smoke and Vapor

2010

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“…(±)-4-Terpineol has also been reported in a number of publications, without any indication of stereochemistry. 32 Cadinol has been reported as the epi-α-isomer (τ-cadinol); 33 however based on GC-MS library data, 27 5 and 11 were identified as α-cadinol esters. γ-Eudesmol has been reported before.…”

mentioning

confidence: 99%

Cannabinoid Ester Constituents from High-PotencyCannabis sativa

et al. 2008

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Eleven new cannabinoid esters, together with three known cannabinoid acids and Δ 9 -tetrahydrocannabinol (Δ 9 -THC), were isolated from a high-potency variety of Cannabis sativa. The structures were determined by extensive spectroscopic analyses to be β-fenchyl Δ 9 -tetrahydrocannabinolate (1), epi-bornyl Δ 9 -tetrahydrocannabinolate (2), α-terpenyl Δ 9 -tetrahydrocannabinolate (3), 4-terpenyl Δ 9 -tetrahydrocannabinolate (4), α-cadinyl Δ 9 -tetrahydrocannabinolate (5), γ-eudesmyl Δ 9 -tetrahydrocannabinolate (6), γ-eudesmyl cannabigerolate (7), 4-terpenyl cannabinolate (8), bornyl Δ 9 -tetrahydrocannabinolate (9), α-fenchyl Δ 9 -tetrahydrocannabinolate (10), α-cadinyl cannabigerolate (11), Δ 9 -tetrahydrocannabinol (Δ 9 -THC), Δ 9 -tetrahydrocannabinolic acid A (Δ 9 -THCA), cannabinolic acid A (CBNA), and cannabigerolic acid (CBGA). Compound 8 showed moderate antimicrobial activity against Candida albicans ATCC 90028 with an IC 50 value of 8.5 μg/mL. CB-1 receptor assay indicated that the esters, as well as the parent acids, are not active.The family Cannabaceae is currently recognized as containing only one genus, namely, Cannabis, which includes only one highly variable species: Cannabis sativa L. Other previously reported species include Cannabis indica Lam. and Cannabis ruderalis Janisch. Plants considered to have belonged to these species are now recognized as varieties of C. sativa L. (var. indica and var. ruderalis, respectively). C. sativa L. has been used by humans for thousands of years, providing fiber for spinning and making paper, seed for human and animal consumption, and aromatic resin for medicinal use. The chemotypes of C. sativa L.can be divided into drug type (marijuana), intermediate type, and fiber type (hemp), with the tetrahydrocannabinol (Δ 9 -THC) content ranging from 1 to 20%, 0.3-1.0%, and <0.3%, respectively. 1-3 Supporting Information Available: HRESIMS, GC-MS, GC-MS trimethylsilyl derivatization, 1 H NMR, 13 C NMR, and selected 2D NMR spectra for compound 1. HPLC chromatograms of isolated compounds. GC-MS data of isolated compounds. This material is available free of charge via the Internet at http://pubs.acs.org. Cannabis is very complex in its chemistry due to the vast number of its constituents and their possible interaction with one another. The compounds reported include many natural product classes, e.g., mono-and sesquiterpenes, sugars, hydrocarbons, steroids, flavonoids, nitrogenous compounds, and amino acids. [4][5][6][7][8][9][10] The best-known and the most specific group of compounds found in cannabis is the C 21 terpenophenolics, the cannabinoids, with (−)-Δ 9 -trans-(6aR,10aR)-tetrahydrocannabinol (Δ 9 -THC) being the most psychoactive constituent. 11 The development of synthetic cannabinoids and the discovery of chemically different endogenous cannabinoid receptor ligands (endocannabinoids) have prompted the use of the term "phytocannabinoids" to describe these compounds. 12 The class cannabinoids can be divided into 11 groups: cannabigerol type (7 known), ca...

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The Volatile Oil Composition of Fresh and Air-Dried Buds of Cannabis sativa

Cited by 149 publications

References 13 publications

Characterization of the Volatile Components of Cannabis Preparations by Solid-Phase Microextraction Coupled to Headspace-Gas Chromatography with Mass Detector (SPME-HSGC/MS)

Characterization of the Volatile Components of Cannabis Preparations by Solid-Phase Microextraction Coupled to Headspace-Gas Chromatography with Mass Detector (SPME-HSGC/MS)

Cannabinoid Receptor 1 Binding Activity and Quantitative Analysis of Cannabis sativa L. Smoke and Vapor

Cannabinoid Ester Constituents from High-PotencyCannabis sativa

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