The vitamin D slant on allergy

Abstract

Oral vitamin D supplementation has been introduced into modern medicine to prevent rickets without the knowledge that this may have profound immunological consequences. The main vitamin D metabolite calcitriol suppresses dendritic cell maturation and consecutive Th(1) cell development, which has independently described as a key mechanism of allergy development. Animal studies and epidemiological surveys now provide a first link of early vitamin D supplementation and later allergy where several vitamin D regulated genes seem to be involved. A randomized clinical trial of vitamin D supplementation could be a further step to follow up the vitamin hypothesis.

Cord Blood 25(OH)-Vitamin D Deficiency and Childhood Asthma, Allergy and Eczema: The COPSAC2000 Birth Cohort Study

“…We found no significant association between cord blood 25(OH)-Vitamin D level and subsequent development of allergic sensitization or allergic rhinitis although the effect estimates showed a trend of decreased risk of allergic outcomes by deficient Vitamin D levels which has also been suggested by others [37].…”

Cord Blood 25(OH)-Vitamin D Deficiency and Childhood Asthma, Allergy and Eczema: The COPSAC2000 Birth Cohort Study

“…We found no significant association between cord blood 25(OH)-Vitamin D level and subsequent development of allergic sensitization or allergic rhinitis although the effect estimates showed a trend of decreased risk of allergic outcomes by deficient Vitamin D levels which has also been suggested by others [37].…”

Food Allergy Prevention and Treatment by Targeted Nutrition

“…Vitamin D has been shown to inhibit the maturation of dendritic cells and impede the development of T-helper 1 responses. In theory, vitamin D therefore could increase the risk of allergic disorders in infancy [103]. This is supported by a recent German birth cohort study (LINA study) which found that high vitamin D levels during pregnancy and at birth were associated with an increased risk of food allergy [104].…”

Potential links between the emerging risk factors for food allergy and vitamin D status

“…However the numbers were small: across these two 25(OH)D categories, only 20 infants had visible eczema and 23 had atopic eczema. There was no reported difference in eczema rates between infants whose mother's 25(OH)D was in an intermediate range (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49), or 50-74 nmol/L) in comparison to those in the lowest or highest categories. At the 9-year review, maternal 25(OH)D 75 nmol/L or greater was positively associated with parent-reported 'asthma', but not parent-reported 'eczema'; but by 9 years, the follow-up rate was only 38% and the outcome measures had low discriminatory value.…”

Cord Blood 25(OH)-Vitamin D Deficiency and Childhood Asthma, Allergy and Eczema: The COPSAC2000 Birth Cohort Study

“…We found no significant association between cord blood 25(OH)-Vitamin D level and subsequent development of allergic sensitization or allergic rhinitis although the effect estimates showed a trend of decreased risk of allergic outcomes by deficient Vitamin D levels which has also been suggested by others [37].…”

Food Allergy Prevention and Treatment by Targeted Nutrition

“…Vitamin D has been shown to inhibit the maturation of dendritic cells and impede the development of T-helper 1 responses. In theory, vitamin D therefore could increase the risk of allergic disorders in infancy [103]. This is supported by a recent German birth cohort study (LINA study) which found that high vitamin D levels during pregnancy and at birth were associated with an increased risk of food allergy [104].…”

Potential links between the emerging risk factors for food allergy and vitamin D status

“…However the numbers were small: across these two 25(OH)D categories, only 20 infants had visible eczema and 23 had atopic eczema. There was no reported difference in eczema rates between infants whose mother's 25(OH)D was in an intermediate range (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49), or 50-74 nmol/L) in comparison to those in the lowest or highest categories. At the 9-year review, maternal 25(OH)D 75 nmol/L or greater was positively associated with parent-reported 'asthma', but not parent-reported 'eczema'; but by 9 years, the follow-up rate was only 38% and the outcome measures had low discriminatory value.…”

Cord Blood 25(OH)-Vitamin D Deficiency and Childhood Asthma, Allergy and Eczema: The COPSAC2000 Birth Cohort Study

“…We found no significant association between cord blood 25(OH)-Vitamin D level and subsequent development of allergic sensitization or allergic rhinitis although the effect estimates showed a trend of decreased risk of allergic outcomes by deficient Vitamin D levels which has also been suggested by others [37].…”

Food Allergy Prevention and Treatment by Targeted Nutrition

“…Vitamin D has been shown to inhibit the maturation of dendritic cells and impede the development of T-helper 1 responses. In theory, vitamin D therefore could increase the risk of allergic disorders in infancy [103]. This is supported by a recent German birth cohort study (LINA study) which found that high vitamin D levels during pregnancy and at birth were associated with an increased risk of food allergy [104].…”

Potential links between the emerging risk factors for food allergy and vitamin D status

“…However the numbers were small: across these two 25(OH)D categories, only 20 infants had visible eczema and 23 had atopic eczema. There was no reported difference in eczema rates between infants whose mother's 25(OH)D was in an intermediate range (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49), or 50-74 nmol/L) in comparison to those in the lowest or highest categories. At the 9-year review, maternal 25(OH)D 75 nmol/L or greater was positively associated with parent-reported 'asthma', but not parent-reported 'eczema'; but by 9 years, the follow-up rate was only 38% and the outcome measures had low discriminatory value.…”