2019
DOI: 10.1093/toxsci/kfz164
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Abstract: Stress-induced mitochondrial calcium (Ca2+) overload is a key cellular toxic effectors and a trigger of cardiomyocyte death during cardiac ischemic injury through the opening of mitochondrial permeability transition pore (mPTP). We previously found that the valosin-containing protein (VCP), an ATPase-associated protein, protects cardiomyocytes against stress-induced death and also inhibits mPTP opening in vitro. However, the underlying molecular mechanisms are not fully understood. Here, we tested our hypothes… Show more

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Cited by 15 publications
(26 citation statements)
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“…In addition, a recent study has shown that an ATPase protein named valosin-containing protein (VCP) is involved in the regulation of mitochondrial Ca 2+ uptake [ 13 ]. VCP belongs to an ATPase associated family with four structural domains [ 87 ]: an N-terminal substrate-binding domain, two ATPase domains, and a C terminal domain.…”
Section: Other Regulators In Mitochondrial Ca 2+ mentioning
confidence: 99%
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“…In addition, a recent study has shown that an ATPase protein named valosin-containing protein (VCP) is involved in the regulation of mitochondrial Ca 2+ uptake [ 13 ]. VCP belongs to an ATPase associated family with four structural domains [ 87 ]: an N-terminal substrate-binding domain, two ATPase domains, and a C terminal domain.…”
Section: Other Regulators In Mitochondrial Ca 2+ mentioning
confidence: 99%
“…Recently, VCP has been found to play an essential role in mitochondrial function, including mitochondrial respiration, ATP production and mPTP opening. Overexpression of the VCP protects cardiomyocyte against stimulated death and reduces the I/R induced infarct size in the heart [ 13 , 90 , 91 , 92 ]. Notably, the most recent study found that VCP protects the heart from the stress by preventing excessive Ca 2+ overload through inhibiting Ca 2+ uptake [ 13 ].…”
Section: Other Regulators In Mitochondrial Ca 2+ mentioning
confidence: 99%
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