volume 66, issue 8, P5018-5029 1992
DOI: 10.1128/jvi.66.8.5018-5029.1992
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Abstract: The v-rel oncogene product from the avian reticuloendotheliosis virus strain T corresponds to a member of the Rel-related family of enhancer-binding proteins that includes both the mammalian 50and 65-kDa subunits of the NF-KB transcription factor complex. However, in contrast to NF-KB, v-Rel has been shown to function as a dominant-negative repressor of KB-dependent transcription in many mature cell types. We now demonstrate that a highly conserved motif within the Rel homology domain of v-Rel containing a con…

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