The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

Latorre, Anna; Rocchi, Lorenzo; Berardelli, Alfredo; Bhatia, Kailash P.; Rothwell, John C.

doi:10.1002/mds.27705

Cited by 55 publications

(54 citation statements)

References 198 publications

(216 reference statements)

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“…How long does the effect of stimulation last? (Latorre et al, 2019). How feasible is supervised home-based chronic stimulation by patients themselves and is there any scope of adaptive tES as per patient need?…”

Section: Resultsmentioning

confidence: 99%

“…Repetitive transcranial magnetic stimulation (rTMS) has been studied most extensively in this regard. It has been evaluated in PD, dystonia, essential tremor, Huntington's chorea, and chronic tic disorders like Tourette syndrome (Latorre et al, 2019). Four additional methods of NIBS, with transcranial electrical stimulation (tES), are also being evaluated as potential therapeutic options in neurodegenerative disorderstranscranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial pulsed current stimulation (tPCS), and transcranial random noise stimulation (tRNS).…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive Transcranial Electrical Stimulation in Movement Disorders

et al. 2020

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Dysfunction within large-scale brain networks as the basis for movement disorders is an accepted hypothesis. The treatment options for restoring network function are limited. Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation are now being studied to modify the network. Transcranial electrical stimulation (tES) is also a portable, cost-effective, and non-invasive way of network modulation. Transcranial direct current stimulation and transcranial alternating current stimulation have been studied in Parkinson's disease, dystonia, tremor, and ataxia. Transcranial pulsed current stimulation and transcranial random noise stimulation are not yet studied enough. The literature in the use of these techniques is intriguing, yet many unanswered questions remain. In this review, we highlight the studies using these four potential tES techniques and their electrophysiological basis and consider the therapeutic implication in the field of movement disorders. The objectives are to consolidate the current literature, demonstrate that these methods are feasible, and encourage the application of such techniques in the near future. Keywords: non-invasive brain stimulation (NIBS), transcranial electrical stimulation (tES), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial pulsed current stimulation (tPCS), transcranial random noise stimulation (tRNS)

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

et al. 2020

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“…Extensive research is covering the relationship between the IO curve parameters and medical conditions. For instance, IO curves can be used as biomarkers for movement disorders [6], [7], epilepsy [8], dementia [9], stroke [10], [11], idiopathic normal pressure hydrocephalus (iNPH) [12], neurodegenerative diseases [13], and various other neurological conditions [14]- [18].…”

Section: Convergence Tolerance Tmentioning

confidence: 99%

Input–Output Slope Curve Estimation in Neural Stimulation Based on Optimal Sampling Principles

Alavi

Goetz

Saif

2021

Preprint

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This paper discusses some of the practical limitations and issues, which exist for the input -- output (IO) slope curve estimation (SCE) in neural, brain and spinal, stimulation techniques. The drawbacks of the SCE techniques by using existing uniform sampling and Fisher-information-based optimal IO curve estimation (FO-IOCE) methods are elaborated. A novel IO SCE technique is proposed with a modified sampling strategy and stopping rule which improve the SCE performance compared to these methods. The effectiveness of the proposed IO SCE is tested on 1000 simulation runs in transcranial magnetic stimulation (TMS), with a realistic model of motor evoked potentials (MEPs). The results show that the proposed IO SCE method successfully satisfies the stopping rule, before reaching the maximum number of TMS pulses in 79.5% of runs, while the estimation based on the uniform sampling technique never converges and satisfies the stopping rule. At the time of successful termination, the proposed IO SCE method decreases the 95th percentile (mean value in the parentheses) of the absolute relative estimation errors (AREs) of the slope curve parameters up to 7.45% (2.2%), with only 18 additional pulses in average compared to that of the FO-IOCE technique. It also decreases the 95th percentile (mean value in the parentheses) of the AREs of the IO slope curve parameters up to 59.33% (16.71%), compared to that of the uniform sampling method. The proposed IO SCE also identifies the peak slope with higher accuracy, with the 95th percentile (mean value in the parentheses) of AREs reduced up to 9.96% (2.01%) compared to that of the FO-IOCE method, and up to 46.29% (13.13%) compared to that of the uniform sampling method.

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“…Repetitive transcranial magnetic stimulation (rTMS) is a promising noninvasive brain modulation technique in improving motor and nonmotor symptoms of PD in addition to pharmacological treatment [ 3 , 4 ]. Although high-quality evidence for rTMS in the clinical setting was limited, different cortical regions have been implicated in benefiting symptoms of PD [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease

Zhuang

Wang²,

et al. 2020

Parkinson's Disease

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Background. Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic tool for Parkinson’s disease (PD), and many stimulation targets have been implicated. We aim to explore whether low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) improves motor and nonmotor symptoms of individuals with PD. Methods. We conducted a randomized, single-blind, sham-controlled parallel trial to compare the effect of 10 consecutive daily sessions of 1 Hz rTMS over right DLPFC on individuals with idiopathic PD between active and sham rTMS group. Primary outcomes were changes in Unified Parkinson’s Disease Rating Scale (UPDRS) part III and Nonmotor Symptom Questionnaire (NMSQ). Secondary outcomes were changes in UPDRS total score, Hamilton Rating Scale for Depression (HRSD), Pittsburgh Sleep Quality Index (PSQI), and Montreal Cognitive Assessment (MoCA). Assessments were completed at baseline, after treatment, and at 1 month, 3 months, and 6 months after treatment. Results. A total of 33 participants with PD were randomized. All participants completed the study and no severe adverse effect was noticed. Compared to baseline, active rTMS showed significant improvements in UPDRS part III and NMSQ at 1 month. Change of scores on UPDRS part III, HRSD, and PSQI persisted for 3 months after rTMS intervention. The beneficial effect on cognitive performance assessed by MoCA was maintained for at least 6 months in the follow-up. No significant changes were observed in the group with sham rTMS. Conclusions. Low-frequency rTMS of right DLPFC could be a potential selection in managing motor and nonmotor symptoms in PD.

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The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

Cited by 55 publications

References 198 publications

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

Input–Output Slope Curve Estimation in Neural Stimulation Based on Optimal Sampling Principles

Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease

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