The use of tissue Doppler imaging in the assessment of diastolic dysfunction in children with chronic lung diseases

Draz, Iman H.; Mostafa, Fatma El Zahraa; AbdelMassih, Antoin F.; El-Sayed, Dalia; El-Kaffas, Rania

doi:10.1186/s43054-020-00027-x

Cited by 3 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased incidence of heart disease in patients with PNS has been reported by previous studies. Tissue Doppler imaging is a practical echocardiographic tool that possesses several advantages, being non-invasive, not time-consuming, relatively available, and software-independent compared to other diagnostic modalities [18]. Tissue Doppler imaging can be used to evaluate the systolic and diastolic myocardial motions, so it can be used to assess both systolic and diastolic dysfunctions Echocardiography can demonstrate structural changes in the heart.…”

Section: Discussionmentioning

confidence: 99%

Conventional Echocardiography Versus Tissue Doppler in Children with Primary Nephrotic Syndrome.

Kamel

AboElnour

El-Gamasy

et al. 2021

GEGET

View full text Add to dashboard Cite

Introduction: Cardiac affection in patients with nephrotic syndrome (NS) may be attributable to malnutrition and activated inflammatory state. Myocardial performance index (MPI) is more sensitive than the classic echocardiographic parameters, particularly in showing subclinical myocardial function compromise. Aim of the study: Tto compare the findings of conventional echocardiography and tissue Doppler imaging in children with NS. Methods: This study was conducted at the outpatient Nephrology Clinic and the Cardiology Unit of Pediatric Department at Fayoum University Hospital. It included 30 patients with primary nephrotic syndrome (PNS) compared with 30 apparently healthy subjects, age-and gender-matched to the diseased group. Participants were subjected to full history taking, thorough clinical examination, anthropometric measurements, and laboratory studies. Conventional echocardiography and tissue Doppler imaging were used for evaluation of ventricular hemodynamics. Results: Conventional echocardiography did not reveal any significant differences between the patients and control subjects. Tissue Doppler imaging showed significant differences in some parameters. The right ventricular (RV) and left ventricular (LV) MPI were high in 30% and 20% of PNS patients, respectively. Both LV and RV dysfunctions were significantly associated with longer duration of disease and treatment as well as higher percentage of relapse, steroid resistance, and intake of immunosuppressives. Conclusion:Both LV and RV dysfunctions may occur in children with PNS. Both conditions were significantly associated with disease duration, treatment duration, relapse, steroid resistance, and administration of immunosuppressive drugs. Tissue Doppler echocardiography is recommended for follow-up of NS patients, particularly those with long disease duration and/or prescribed immunosuppressive drugs.

show abstract

Section: Discussionmentioning

confidence: 99%

Conventional Echocardiography Versus Tissue Doppler in Children with Primary Nephrotic Syndrome.

Kamel

AboElnour

El-Gamasy

et al. 2021

GEGET

View full text Add to dashboard Cite

show abstract

Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3

Wagdy,

Fathy,

Elnekidy

et al. 2023

Pediatr Radiol

View full text Add to dashboard Cite

Background Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease. Objective In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using cardiac magnetic resonance imaging (MRI), tissue Doppler echocardiography and serum galectin-3. Materials and methods The study included 34 children with sickle cell disease who were compared with a similar number of healthy controls. Cardiac MRI was used to evaluate late gadolinium enhancement, native T1 mapping, extracellular volume, and T2* for estimation of iron load. Cardiac function and myocardial performance index (MPI, evaluated by tissue Doppler echocardiography) and serum galectin-3 were compared to controls. Results The mean age of the included patients was 13.3 ± 3.2 years. Myocardial iron load by T2* was normal. The mean level of extracellular volume (35.41 ± 5.02%) was significantly associated with the frequency of vaso-occlusive crises (P = 0.017) and negatively correlated with hemoglobin levels (P = 0.005). Galectin-3 levels were significantly higher among cases than controls (P = 0.00), at a cutoff value on the receiver operating characteristic curve of 6.5 ng/ml, sensitivity of 82.5% and specificity of 72.8%. The extracellular volume was significantly higher in cases, with a MPI > 0.4. Conclusion Diffuse interstitial myocardial fibrosis can be detected early in children with sickle cell disease using T1 mapping and is associated with a high frequency of vaso-occlusive crisis. MPI of the left ventricle and serum galectin-3 are recommended screening tools for subclinical cardiac abnormalities. Graphical abstract

show abstract

Evaluation of Cardiac Fibrosis and Subclinical Cardiac Changes in Sickle Cell Children by Magnetic Resonance Imaging, Echocardiography and Serum Galectin-3

Wagdy

Fathy

Elnekidy

et al. 2023

Preprint

View full text Add to dashboard Cite

Cardiovascular complications account for about one third of the premature mortality rate in patients with sickle cell disease (SCD). Underlying this cardiac risk is a progressive cardiomyopathy which is multifactorial. Recently myocardial fibrosis is assumed to be a novel mechanism for cardiac dysfunction. This study aimed to detect cardiac fibrosis and subclinical cardiac changes in sickle cell children by; cardiac magnetic resonance imaging (CMR), Tissue Doppler Echocardiography (TDE) and Galectin-3. Children with SCD were subjected to assessment of cardiac function by TDE and had estimated serum level of Gal-3. Cardiac MRI was used to assess volumes and function by cine sequence, LGE for detection of focal myocardial fibrosis, native T1 mapping and extracellular volume (ECV) for quantification of diffuse myocardial fibrosis as well as CMR T2* for myocardial iron load. Thirty-four childrenwith SCD (mean age 13.32 ± 3.24 years) were enrolled in our study, another thirty-four healthy children served as controls. Although myocardial iron load by T2* was normal, ECV was increased among all cases with mean level 35.41 ± 5.02 %. The mean of ECV was significantly associated with the frequency of VOCs (P= 0.017) and negatively correlated to hemoglobin level (P=0.005). In consistent with ECV, Galectin-3 level was significantly higher among cases when compared to controls (7.75 ± 1.86 ng/ml versus 6.04 ±1.64 ng/ml, p<0.001) with cutoff value over the ROC curve 6.5ng/ml, sensitivity; 82.5 %, specificity; 72.8%. ECV were significantly higher for cases with Tie index > 0.4 by TDI subgroup when compared to ECV of subgroup with Tie index < 0.4 (38.17 ± 4.25 versus 34.43 ± 5.02, P: 0.03*). In conclusion: ECV is a validated CMR parameter to detect and quantify diffuse interstitial myocardial fibrosis in asymptomatic children with SCD. Cardiac fibrosis in SCD children is associated with frequent attacks of ischemic re-perfusion injury and correlated to the severity of anemia rather than myocardial iron load. Tie index by TDE and serum Gal-3 are recommended screening tools.

show abstract

The use of tissue Doppler imaging in the assessment of diastolic dysfunction in children with chronic lung diseases

Cited by 3 publications

References 19 publications

Conventional Echocardiography Versus Tissue Doppler in Children with Primary Nephrotic Syndrome.

Conventional Echocardiography Versus Tissue Doppler in Children with Primary Nephrotic Syndrome.

Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3

Evaluation of Cardiac Fibrosis and Subclinical Cardiac Changes in Sickle Cell Children by Magnetic Resonance Imaging, Echocardiography and Serum Galectin-3

Contact Info

Product

Resources

About