The Use of Tetracyclines for the Treatment of Sarcoidosis

Bachelez, Hervé; Senet, Patricia; Cadranel, J.; Kaoukhov, Alexandre; Dubertret, Louis

doi:10.1001/archderm.137.1.69

Cited by 230 publications

(117 citation statements)

References 26 publications

(23 reference statements)

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“…Therefore, further evaluation of larger numbers of patients in randomized, well-controlled studies is still necessary. Finally, although minocycline is recommended for the aforementioned skin disorders, current therapy has moved towards the use of doxycycline, which has a similar efficacy for the treatment of these conditions with a reduced incidence of adverse effects, such as drug hypersensitivity syndrome, hyperpigmentation and dizziness, frequently associated with minocycline therapy (Bachelez et al, 2001;Sapadin and Fleischmajer, 2006;Korting and Schöllmann, 2009). …”

Section: Effects Of Minocycline On Dermatitismentioning

confidence: 99%

Minocycline: far beyond an antibiotic

Garrido-Mesa

Zarzuelo

Gálvez

2013

British J Pharmacology

757

597

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Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic use for over 30 years because of its antibiotic properties against both gram‐positive and gram‐negative bacteria. It is mainly used in the treatment of acne vulgaris and some sexually transmitted diseases. Recently, it has been reported that tetracyclines can exert a variety of biological actions that are independent of their anti‐microbial activity, including anti‐inflammatory and anti‐apoptotic activities, and inhibition of proteolysis, angiogenesis and tumour metastasis. These findings specifically concern to minocycline as it has recently been found to have multiple non‐antibiotic biological effects that are beneficial in experimental models of various diseases with an inflammatory basis, including dermatitis, periodontitis, atherosclerosis and autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease. Of note, minocycline has also emerged as the most effective tetracycline derivative at providing neuroprotection. This effect has been confirmed in experimental models of ischaemia, traumatic brain injury and neuropathic pain, and of several neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease, multiple sclerosis and spinal cord injury. Moreover, other pre‐clinical studies have shown its ability to inhibit malignant cell growth and activation and replication of human immunodeficiency virus, and to prevent bone resorption. Considering the above‐mentioned findings, this review will cover the most important topics in the pharmacology of minocycline to date, supporting its evaluation as a new therapeutic approach for many of the diseases described herein.

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Section: Effects Of Minocycline On Dermatitismentioning

confidence: 99%

Minocycline: far beyond an antibiotic

Garrido-Mesa

Zarzuelo

Gálvez

2013

British J Pharmacology

757

597

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“…Bachelez et al reported on the use of minocycline in 12 patients; the drug was effective for the treatment of skin lesions in 10 patients and diminished lung disease in 2 [69]. Several mechanisms have been proposed supporting the use of tetracyclines and their analogues in sarcoidosis.…”

Section: Therapy Medicationsmentioning

confidence: 99%

Untitled

2016

JCMK

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Sarcoidosis is a systemic autoimmune disease characterized by noncaseatinggranulomatous inflammation with unknown etiology.Although the lungs and respiratory system are most commonlyinvolved, sarcoidosis may involve virtually any part of the body,including the locomotor system, eyes, skin, lymph nodes. Diagnosis attained via consensus between the clinical presentation and natural history, pattern of major organ involvement, confirmatory biopsy, and response to therapy. Histopathological features remain the gold standard in diagnosis. Radiologic staging in sarcoidosis is based on the chest X-ray. If chest radiographis normal, high-resolution computed tomography (HRCT) can demonstrate pathological changes in a detailed manner. Sarcoidosis generally follows a benign course with occasional spontan remissions. The most important causes of mortality are acute and chronic respiratory failure, pulmonary hypertension and hemoptysis due to aspergillosis. When treatment is indicated, glucocorticoids remain the only recognized effective therapy for active sarcoidosis. Level of evidence for management of sarcoidosis is low, generally reflecting the results of limited number of clinical studies, case series and expert opinion. In selected cases, biological agents including, tumour necrosis factor inhibitors, seem to be promising.Keywords: Sarcoidosis -diagnosis -treatment. Тұжырымдама Саркоидоз, казеозды емес, гранулематозды қабынуымен сипатталатын этиологиясы белгісіз жүйелі аутоиммунды ауру. Өкпе және тыныс алу жүйесінің ең жиі зақымдалуына қарамастан, саркоидоз адам ағзасының кез келген бөлігін, соның ішінде тірек-қимыл жүйесі, көз, тері, лимфа түйіндерін қамтуы мүмкін. Диагноз клиникалық белгілері және шынайы ауру тарихы, ірі мүше зақымдауын растайтын биопсия-сымен, терапияға жауап беру консенсус арқылықоюлуда. Гистопатологиялық ерекшеліктері диагностикада алтын стандарт болып қалуда. Рентгенологиялық зерттеуде кеуде қуысы рентгенографиялық тұрғыдан қалыпты болса, ажыратымдылығы жоғары компьютерлік томогра-фия (HRCT) арқылы егжей-тегжейлі түрде патологиялық өзгерістерін көрсете алады. Саркоидоз, әдетте зарарсыз ағымды, кездейсоқ кенет-тен ремиссиясы кездесетін ауру. Өлімнің ең маңызды себептері жедел және созылмалы тыныс жетіспеушілігі, өкпелік гипертензия, аспер-гиллез салдарынан қан құсу болып табылады. Саркоидоздың белсенді түрінде ең тиімді сапалы ем глюкокортикоидтар болып табылады. Саркоидозды бақылау және басқару үшін дәлелдемелер деңгейінің төмендігін, әдетте, клиникалық зерттеулер, бақылау серияларының және сараптамалық қорытынды саны шектеулі нәтижелерін көрсетеді. Таңдалған жағдайларда ісіктердің некроздық фактор ингибиторлары, оған қоса алғанда, биологиялық агенттері перспективалы болып көрінеді. J Clin Med Kaz 2016; 3(41):6-13Маңызды сөздер: саркоидоз -диагностикасы -емі.Саркоидоз: взгляд терапевта тыназлы М., Бахтиярова г.Клиника Ближневосточного университета, медицинский факультет, кафедра Внутренних болезней, Никосия РезюмеСаркоидоз представляет собой системное аутоиммунное заболевание, характеризу...

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“…In a study with 12 patients Bachelez, et. al administered minocycline resulting in 8 patients with complete clearance of sarcoidosis, of which 7 could be completely removed from therapy, however 3 of these 7 patients subsequently required additional treatment with minocycline due to relapse [129]. Administering minocycline to a sarcoidosis patient resulted in initial regression of lesions, but was followed by remission [130].…”

Section: Antimicrobialmentioning

confidence: 99%

Sarcoidosis: Unknown Etiology and Genetic Predisposition Provides Therapeutic Challenges

Rotsinger

Drake²

2014

J Pulm Respir Med

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Sarcoidosis is an idiopathic multisystem disorder characterized by noncaseating epithelioid granulomas predominately affecting lungs and lymph nodes, but with potential to affect any organ system. Sarcoidosis shares similarities in development to other infectious granulomatous diseases, such as berylliosis and tuberculosis; however, its elusive etiology and non-distinctive histology have provided many diagnostic challenges. Evidence of a transferrable antigen combined with a high incidence rate in the lungs has focused efforts primarily on antigens with airborne transmissibility. While Mycobacterium tuberculosis and Propionibacterium acnes have provided strong associations to implicate each as a contributor to sarcoidosis pathogenesis, detection challenges remain and consensus of a definitive antigen is lacking.

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The Use of Tetracyclines for the Treatment of Sarcoidosis

Cited by 230 publications

References 26 publications

Minocycline: far beyond an antibiotic

Minocycline: far beyond an antibiotic

Untitled

Sarcoidosis: Unknown Etiology and Genetic Predisposition Provides Therapeutic Challenges

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