The Use of Prophylactic Low Dose Heparin in Transurethral Prostatectomy

Kass, Evan J.; Sonda, Paul L.; Gershon, Charles; Fischer, C. Peter

doi:10.1016/s0022-5347(17)57099-8

Cited by 11 publications

(3 citation statements)

References 12 publications

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“…Of drugs contributing to haemorrhage after prostatectomy the most commonly studied is heparin, administered subcutaneously as prophylaxis for venous thrombo-embolism. Conflicting results have been reported (Halverstadt et al, 1977;Kass et al, 1978;Sleight, 1982;Bejjani et al, 1983;Wilson et al, 1988). There have been few studies on the effect of aspirin on post-prostatectomy haemorrhage but its effect after other surgical procedures is well documented.…”

Section: Discussionmentioning

confidence: 99%

Identifiable Factors in Post‐prostatectomy Haemorrhage: the Role of Aspirin

Deane

Doyle

et al. 1990

British Journal of Urology

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Post-operative haemorrhagic complications following the ingestion of aspirin have been reported after several types of surgery, most notably coronary artery bypass surgery. In this study, aspirin ingestion also appeared to be a significant aetiological factor in post-prostatectomy haemorrhage. This is explained in terms of its inhibitory effect on platelet aggregation. A history of aspirin ingestion should be carefully sought and its haemorrhagic implications considered prior to prostatectomy.

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Section: Discussionmentioning

confidence: 99%

Identifiable Factors in Post‐prostatectomy Haemorrhage: the Role of Aspirin

Deane

Doyle

et al. 1990

British Journal of Urology

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“…Several studies have been performed relating the use of subcutaneous heparin to blood loss during TURP, but their results are conflicting. Halverstadt et al (1977), Allen et al (1 978) and Sleight (1982) concluded that subcutaneous heparin increased haemorrhage, whereas Kass et al (1978), Miller and Butz (1981) and Bejani et al (1983) concluded that it did not. Most of these studies were either retrospective or used historical controls.…”

mentioning

confidence: 99%

Prophylactic Subcutaneous Heparin does not Increase Operative Blood Loss in Transurethral Resection of the Prostate

Wilson¹,

Smith²,

Paton³

et al. 1988

British Journal of Urology

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A prospective randomised study of subcutaneous heparin compared with no heparin was performed in 60 patients undergoing transurethral resection of the prostate. Operative blood loss in the irrigation fluid was measured using a haemoglobinometer. Blood loss correlated with the amount of prostate resected and the duration of the procedure. Subcutaneous heparin had no significant effect on the measured blood loss in transurethral resection of the prostate and can be used as a safe means of prophylaxis against thrombo-embolic complications.

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“…In TIJRP, postoperative blood loss can be accurately measured, allowing objective determination of bleeding possibly induced by heparin or associated compounds (14). Previous studies using standard heparin were controversial showing results of either increased blood loss, or no effect on postoperative haemorrhage (17, 18,19). It has been claimed on the basis of animal experiments that LMW heparins and heparinoids caused less bleeding than standard heparin (3, 4,20) .…”

Section: Discussionmentioning

confidence: 99%

Randomized Double-Blind, Placebo Controlled Safety Study of a Low Molecular Weight Heparinoid in Patients Undergoing Transurethral Resection of the Prostate

et al. 1987

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SummaryIn preparation for an efficacy study, the effect of the low molecular weight heparinoid Org 10172 on postoperative blood loss was assessed in a randomized double-blind, placebo controlled study in patients undergoing transurethral resection of the prostate (TURP). Org 10172 and placebo were given twice daily as i.v. injection for three postoperative days starting one hour preoperatively. Three doses of Org 10172 (800, 1600, and 2400 anti-Xa units b.d.) were evaluated against placebo in three consecutive patient blocks respectively. Each block consisted of 20 patients, 15 receiving Org 10172 and 5 patients placebo. The study was discontinued after 9 patients of the third block had completed the protocol because of excessive urinary blood loss. Data analysis showed a dose-dependent increase in postoperative haemoglobin loss, this was not significant for the 800 anti-Xa units b. d. dosage but was significant in those patients treated with 1600 (p <0.05) and 2400 anti-Xa units b.d. (p <0.01).It was concluded that the heparinoid Org 10172 caused a dose dependent increase in urinary blood loss following TURP.

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The Use of Prophylactic Low Dose Heparin in Transurethral Prostatectomy

Cited by 11 publications

References 12 publications

Identifiable Factors in Post‐prostatectomy Haemorrhage: the Role of Aspirin

Identifiable Factors in Post‐prostatectomy Haemorrhage: the Role of Aspirin

Prophylactic Subcutaneous Heparin does not Increase Operative Blood Loss in Transurethral Resection of the Prostate

Randomized Double-Blind, Placebo Controlled Safety Study of a Low Molecular Weight Heparinoid in Patients Undergoing Transurethral Resection of the Prostate

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