The Use of Omeprazole in the Pediatric Population

Walters, Jennifer; Zimmermann, Anthony E.; Souney, Paul F.; Katona, Brian G.

doi:10.1345/aph.17210

Cited by 11 publications

(3 citation statements)

References 22 publications

(8 reference statements)

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“…9 PPIs are more effective than H 2 antagonists, well tolerated, and safe. 9,[117][118][119][120][121][122][123][124][125][126][127] Limited side effects are reported in 1% to 6% of patients. 9 The long-term safety of PPIs in children is still a matter of concern despite that large and long follow-up (up to 11 years) studies in adults showed neither serious adverse events 128 nor gastric dysplasia, neoplasia, inflammation, atrophy, or argyrophil cell hyperplasia in Helicobacter pylori-negative patients.…”

Section: Proposed Diagnostic and Therapeutic Approachmentioning

confidence: 99%

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Salvatore¹,

Vandenplas

2002

Pediatrics

110

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Gastroesophageal reflux (GER) and cow milk allergy (CMA) occur frequently in infants younger than 1 year. In recent years, the relation between these 2 entities has been investigated and some important conclusions have been reached: in up to half of the cases of GER in infants younger than 1 year, there may be an association with CMA. In a high proportion of cases, GER is not only CMA associated but also CMA induced. The frequency of this association should induce pediatricians to screen for possible concomitant CMA in all infants who have GER and are younger than 1 year. With the exception of some patients with mild typical CMA manifestations (diarrhea, dermatitis, or rhinitis), the symptoms of GER associated with CMA are the same as those observed in primary GER. Immunologic tests and esophageal pH monitoring (with a typical pH pattern characterized by a progressive, slow decrease in esophageal pH between feedings) may be helpful if an association between GER and CMA is suspected, although the clinical response to an elimination diet and challenge is the only clue to the diagnosis. This article reviews the main features of GER and CMA, focusing on the aspects in common and the discrepancies between both conditions.

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Section: Proposed Diagnostic and Therapeutic Approachmentioning

confidence: 99%

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Salvatore¹,

Vandenplas

2002

Pediatrics

110

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“…9 If the prescribed dosage of lansoprazole or omeprazole is not equivalent to the marketed dosage strength, options include compounding a suspension using sodium bicarbonate (see Tables 1 and 2) or administering a portion of a tablet. 10,11 The Hospital for Sick Children in Toronto does not recommend formulations with sodium bicarbonate due to concerns associated with the sodium and/or bicarbonate load. 12 Their practice for omeprazole is as follows:…”

Section: Administrationmentioning

confidence: 99%

Proton Pump Inhibitors in Pediatric Patients

Fan¹,

Gavura²,

Ruddock³

2006

Can Pharm J

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“…Of these, the proton pump inhibitors (PPI) have been the best studied, although experience in infants and children is limited. 27,28 The PPI are effective in suppressing acidity in patients with gastric stress ulcers and also in neurologically impaired children. Even in patients with circular oesophageal ulcerations, recent experience suggests that PPI should be tried prior to surgery.…”

Section: Overt Gastro‐oesophageal Reflux Diseasementioning

confidence: 99%

Diagnosis and treatment of gastro‐oesophageal reflux disease in infants and children

Vandenplas¹,

Hegar²

2000

J of Gastro and Hepatol

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Gastro‐oesophageal reflux is a frequent, aspecific phenomenon in infants and children. The recommended approach in infants with uncomplicated regurgitation consists of reassurance of the parents and, if this fails, dietary recommendations in formula‐fed infants. If, despite these efforts, symptoms persist, administration of prokinetics, such as cisapride, is recommended prior to investigations such as oesophageal pH monitoring. Oesophageal pH monitoring is also recommended to document gastro‐oesophageal reflux disease in children with unusual presentations such as chronic respiratory disease. Today, cisapride is the drug of choice because it has the best efficacy and safety profile. In infants and children presenting with symptoms suggesting oesophagitis, endoscopy of the upper gastrointestinal tract is recommended. If there is severe oesophagitis, acid suppression with histamine H2‐receptor antagonists or proton pump inhibitors in combination with prokinetics, are recommended. In life‐threatening situations, or in patients that are resistant to or dependent on acid‐suppressive medication, a surgical procedure such as laparascopic Nissen procedure should be considered.

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The Use of Omeprazole in the Pediatric Population

Cited by 11 publications

References 22 publications

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Proton Pump Inhibitors in Pediatric Patients

Diagnosis and treatment of gastro‐oesophageal reflux disease in infants and children

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