The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat

Chakraborty, Somsuta; Stalin, Sami; Das, Nirmalendu; Choudhury, Somnath Ray; Ghosh, Swarupa; Swarnakar, Snehasikta

doi:10.1016/j.biomaterials.2011.12.037

Cited by 134 publications

(86 citation statements)

References 34 publications

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“…134 Similarly, quercetin nanoparticles showed 20-fold increased efficiency and controlled ethanol-induced gastric ulcers in rats. 135 Synthetic PLGA-coated nanoparticles, such …”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…194 Nanosizing quercetin greatly increases bioavailability and increases the protective effect at the target site without much loss in the gastrointestinal tract during oral administration. 98,135,[195][196][197] Oral delivery of nanoencapsulated quercetin with a size of 270 nm protects rat brain and liver cells from toxicity induced by arsenic. These studies have confirmed that quercetin is highly protected in the gastrointestinal tract and can be safely delivered to the target site in the brain.…”

Section: Nanoquercetinmentioning

confidence: 99%

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Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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“…134 Similarly, quercetin nanoparticles showed 20-fold increased efficiency and controlled ethanol-induced gastric ulcers in rats. 135 Synthetic PLGA-coated nanoparticles, such …”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Nanoquercetinmentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

View full text Add to dashboard Cite

show abstract

“…For example, nanocapsulated quercetin employing poly(d,l-lactic-co-glycolic acid) showed higher efficacy over free quercetin in the prevention of ethanol-induced gastric ulcer in rats. 25 Potentiated anticancer activity of naringenin against human cervical (HeLa) cancer cells upon loading into Eudragit E nanoparticles has been documented in the literature. 26 Polymeric micelles have been emerged as a successful approach for the site-specific delivery of various drugs.…”

mentioning

confidence: 99%

Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Mohamed¹,

Hashim²,

Yusif³

et al. 2018

IJN

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Naringin is one of the most interesting phytopharmaceuticals that has been widely investigated for various biological actions. Yet, its low water solubility, limited permeability, and suboptimal bioavailability limited its use. Therefore, in this study, polymeric micelles of naringin based on pluronic F68 (PF68) were developed, fully characterized, and optimized. The optimized formula was investigated regarding in vitro release, storage stability, and in vitro cytotoxicity vs different cell lines. Also, cytoprotection against ethanol-induced ulcer in rats and antitumor activity against Ehrlich ascites carcinoma in mice were investigated. Nanoscopic and nearly spherical 1:50 micelles with the mean diameter of 74.80±6.56 nm and narrow size distribution were obtained. These micelles showed the highest entrapment efficiency (EE%; 96.14±2.29). The micelles exhibited prolonged release up to 48 vs 10 h for free naringin. The stability of micelles was confirmed by insignificant changes in drug entrapment, particle size, and retention (%) (91.99±3.24). At lower dose than free naringin, effective cytoprotection of 1:50 micelles against ethanol-induced ulcer in rat model has been indicated by significant reduction in mucosal damage, gastric level of malondialdehyde, gastric expression of tumor necrosis factor-alpha, caspase-3, nuclear factor kappa-light-chain-enhancer of activated B cells, and interleukin-6 with the elevation of gastric reduced glutathione and superoxide dismutase when compared with the positive control group. As well, these micelles provoked pronounced antitumor activity assessed by potentiated in vitro cytotoxicity particularly against colorectal carcinoma cells and tumor growth inhibition when compared with free naringin. In conclusion, 1:50 naringin–PF68 micelles can be represented as a potential stable nanodrug delivery system with prolonged release and enhanced antiulcer as well as antitumor activities.

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“…Ethanol inhibits the mitochondrial electron transfer system and increases reactive oxygen species (ROS) production, thus causing cellular injury [8]. The imbalance between the production and the elimination of ROS plays an important role in gastric mucosal injury [9]. The neutrophil infiltration in gastric mucosa induced by ethanol has been shown to be closely related to the formation of lesions [10].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

Tanyeli

Eraslan

Polat

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Alcohol consumption has been found to be associated with gastric ulcers, including gastric mucosal lesions. Salusin-α and salusin-β are bioactive peptides having 28 and 20 amino acids, respectively. Salusin-α and salusin-β immunoreactivity has been detected in the stomach and in the intestines. It has been reported that the salusins regulate the cytokine levels and decrease the infarct area in the heart tissue after ischemia. In this study, we investigated the effects of the salusins in the gastric injury formed with ethanol. Methods: Thirty-two sprague Dawley male rats were randomly divided into four groups, including eight rats in each group as follows: Group 1: control; Group 2: ethanol 5 mL/kg; Group 3: ethanol 5 mL/kg + 5 nmol/kg salusin-α; Group 4: ethanol 5 mL/kg + 5 nmol/kg salusin-β. Results: The salusin-α level increased at a significant level in the ulcer group formed with ethanol (p < 0.001); the change in the salusin-β level is not significant. As for malondialdehyde (p < 0.05) and myeloperoxidase (p < 0.001), when compared with the control group, tumor necrosis factor-α (p < 0.05) levels increased in the group to which ethanol was applied and decreased significantly with the application of salusins. Levels of GSH and IL-1β did not change at a significant level. In addition, histopathologic analysis demonstrated that, in salusin-administered groups, mucosal injury and caspase-3 expressions were reduced. Conclusions: The suppression of salusin-α and salusin-β on caspase-3 expression by means of their effects on

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The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat

Cited by 134 publications

References 34 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

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The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat

Cited by 134 publications

References 34 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

Contact Info

Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models