The use of microwave irradiation in the fluorous synthesis

Abstract

Fluorous Synthesis employs perfluoroalkyl (Rf) hai s as phase tags to i prove the effi ie y of the purification of reaction mixtures. This method allied to microwave irradiation led to compounds in high yields and chemical diversity in shorter time. This manuscript presents the fluorous synthesis and explores the advantages of the microwave fluorous synthesis. Futhermore, some papers from the recent literature are quickly presented.

Fluorous Supported Synthesis of Pyrazolone Derivatives From Allylic Alcohols Using a Palladium-Catalyzed Strategy

“…[26][27][28][29] We herein report an efficient synthetic route to some structurally diverse pyrazolone derivatives from perfluorinated allylic alcohols. We investigated the palladium-catalyzed transformation of allylic alcohols to β-ketoesters and their subsequent cyclization into pyrazolones.…”