The use of low-volume dosing in the eye irritation test

Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique

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Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique

“……”

Soaps and Detergents: Alternatives to Animal Eye Irritation Tests

“…Topical ophthalmic anesthetics were proposed to lessen pain in test animals, but their use was not found to be entirely satisfactory (Seabaugh et al, 1993). Lessening the quantity of test material 10-fold (from the 0.1 ml required in the Draize eye irritation procedure) has also become an acceptable modification (Lambert et al, 1993). Studies with 22 test materials conducted by the Soap and Detergent Association (Bagley et al, 1994) have shown that a 93% correlation exists between results from this low-volume eye test and the Draize eye irritation test.…”

An overview of current techniques for ocular toxicity testing

“…LVET is a refinement of Draize testing developed by Griffith et al (1980). The primary difference to the Draize test is that lower volumes of test substances (0.01 ml/0.01 g) (Lambert et al, 1993) are applied to the right-eye of the animal (Maurer et al, 2002), with no forced eyelid closure employed (ICCVAM, 2010b). Test substances are also only applied to the corneal surface and not the conjunctival sac.…”

Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique

“……”

Soaps and Detergents: Alternatives to Animal Eye Irritation Tests

“…Topical ophthalmic anesthetics were proposed to lessen pain in test animals, but their use was not found to be entirely satisfactory (Seabaugh et al, 1993). Lessening the quantity of test material 10-fold (from the 0.1 ml required in the Draize eye irritation procedure) has also become an acceptable modification (Lambert et al, 1993). Studies with 22 test materials conducted by the Soap and Detergent Association (Bagley et al, 1994) have shown that a 93% correlation exists between results from this low-volume eye test and the Draize eye irritation test.…”

An overview of current techniques for ocular toxicity testing

“…LVET is a refinement of Draize testing developed by Griffith et al (1980). The primary difference to the Draize test is that lower volumes of test substances (0.01 ml/0.01 g) (Lambert et al, 1993) are applied to the right-eye of the animal (Maurer et al, 2002), with no forced eyelid closure employed (ICCVAM, 2010b). Test substances are also only applied to the corneal surface and not the conjunctival sac.…”

Comprehensive evaluation of formulation factors for ocular penetration of fluoroquinolones in rabbits using cassette dosing technique

“……”

Soaps and Detergents: Alternatives to Animal Eye Irritation Tests

“…Topical ophthalmic anesthetics were proposed to lessen pain in test animals, but their use was not found to be entirely satisfactory (Seabaugh et al, 1993). Lessening the quantity of test material 10-fold (from the 0.1 ml required in the Draize eye irritation procedure) has also become an acceptable modification (Lambert et al, 1993). Studies with 22 test materials conducted by the Soap and Detergent Association (Bagley et al, 1994) have shown that a 93% correlation exists between results from this low-volume eye test and the Draize eye irritation test.…”

An overview of current techniques for ocular toxicity testing

“…LVET is a refinement of Draize testing developed by Griffith et al (1980). The primary difference to the Draize test is that lower volumes of test substances (0.01 ml/0.01 g) (Lambert et al, 1993) are applied to the right-eye of the animal (Maurer et al, 2002), with no forced eyelid closure employed (ICCVAM, 2010b). Test substances are also only applied to the corneal surface and not the conjunctival sac.…”