The use of LeptiCore® in reducing fat gain and managing weight loss in patients with metabolic syndrome

Abstract

BackgroundLeptiCore® is a proprietary combination of various ingredients which have been shown to have properties which could be beneficial to weight loss in obese and overweight human subjects. This study evaluates the effect of Lepticore® on bodyweight as well as parameters associated with obesity and metabolic syndrome.MethodsThe study was an 8 week randomized, double-blind, placebo-controlled design involving 92 obese (mean BMI > 30 kg/m2) participants (37 males; 55 females; ages 19-52; mean age = 30.7). The participants were randomly divided into three groups: placebo (n = 30), LeptiCore® formula A (low dose) (n = 31) and LeptiCore® formula B (high dose) (n = 31). Capsules containing the placebo or active formulations were administered twice daily before meals with 300 ml of water. None of the participants followed any specific diet nor took any weight-reducing medications for the duration of the study. A total of 12 anthropomorphic and serological measurements were taken at the beginning of the study and after 2, 4, 6, and 8 weeks of treatment.ResultsCompared to the placebo group, the two active groups showed statistically significant differences on all 12 variables by week 8. These included four anthropomorphic variables (body weight, body fat, waist and hip size) and eight measures of serological levels (plasma total cholesterol, LDL, HDL, triglycerides, blood glucose, serotonin, leptin, C-reactive protein). The two active groups also showed significant intra-group differences on all 12 variables between study onset and week 8.ConclusionThe LeptiCore® formulation at both the low and high dosages appears to be helpful in the management of fat gain and its related complications. The higher dosage resulted in significantly greater reductions in body weight and triglyceride, blood glucose, and C-reactive protein levels, as well as increased serotonin levels.

Urbanization and Metabolic Syndrome in Cameroon: Alertness on Less Urbanised Areas

“…Waist circumference measurements to the nearest 0.1 cm were taken at the mid-point between the bottom rib and the hip bone, without restrictive garments using a flexible non expandable tape measure. Body Mass Index (BMI) was calculated by the formula BMI = Weight (kg) / Height 2 (m) and expressed as kg/m 2 [14].…”

Body Mass Index, Blood Pressure and Hypertension Subtypes among Untreated Hypertensive Cameroonians

“…Waist and hip measures were obtained with a soft non-stretchable plastic tape to the nearest 0.5 cm. Waist circumference was measured on the narrowest and the widest part of the trunk; hip circumference was obtained at the widest point of the hip [15].…”

The Use of Cissus quadrangularis (CQR-300) in the Management of Components of Metabolic Syndrome in Overweight and Obese Participants

“…A study conducted on another C. quadrangularis product, Lepticore TM , demonstrated weight loss of 5.4% obtained at a single dose (300 mg, Formula A) and 6.95% with Formula B (300 mg, twice daily). LeptiCore®, a proprietary blend of plant-based polysaccharides, esterified fatty acids, pomegranate, polyphenols, ellagic acid, beta carotene, and Aphanizomenon flosaquae extract, again showed less weight loss, despite the extra components [11].…”

“…In Table 12, serotonin levels significantly increased at 4 weeks (p<0.05) and 8 weeks (p<0.01) at about 3.4 times in the overweight group (115.7 ± 43.1%), but less in the obese group (34.2 ± 9.6%) compared with the placebo groups. The single dose of 300 mg of CQR-300 demonstrated more activity in serotonin production than the same single dose of Lepticore TM (28.6%) [11]. C. quadrangularis phytosterols and fiber extracts have been shown to have anti-lipase, and anorexiant properties that reduce the absorption of dietary fats and enhance satiation by increasing serum serotonin levels [17].…”

“…Total cholesterol in plasma was determined using an enzymatic method, while plasma triglyceride was determined as previously described [11]. HDL cholesterol was determined using a heparin manganese precipitation of Apo Bcontaining lipoproteins.…”