volume 272, issue 1-2, P121-128 2004
DOI: 10.1016/j.ijpharm.2003.12.007
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Abstract: It is known that acids and bases when mixed together have the potential to react, however, there is complexity when materials are in the solid state, as the surface of the solids may not have all functional groups of the molecule expressed in equal proportions. Conceptually a drug that is acidic when in solution could have a crystal surface that is largely basic (if the acid groups are aligned away from the surface). The interaction of cefditoren pivoxil (a basic drug when dissolved) and various Eudragit polym…

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