The use of high-frequency ultrasound as a method of assessing the severity of a plaque of psoriasis

Gupta, Aditya K.

doi:10.1001/archderm.132.6.658

Cited by 33 publications

(55 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High-frequency ultrasound (US) is another imaging technique capable of measuring psoriatic plaque thickness (4). The recent introduction and application of these instruments in association with clinical observation, has allowed researchers to objectively quantify psoriasis severity and to evaluate therapeutic response in patients undergoing anti-psoriatic treatment.…”

mentioning

confidence: 99%

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Musumeci

Lacarrubba

et al. 2013

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Imaging techniques have only recently been utilized in combination with clinical observation to objectively quantify psoriasis severity and evaluate therapeutic response. This study evaluated the sensitivity of videodermatoscopy (VO) and ultrasound (US) imaging to assess the therapeutic effect of cyclosporine (Cs) in patients with moderate-to-severe psoriasis. Twenty patients with moderate-tosevere psoriasis were divided into two groups (A and B) based on PASI score. Group A (PASI >16) was treated with 5 mg/Kg/day Cs for 4 weeks and another 4 weeks with 3 mg/Kg/day Cs. Group B (PASI 10-16) received 3 mg/Kg/day Cs for 8 weeks. A "target" plaque was selected for each subject and evaluated using a Target Lesion Score (TLS) for erythema, scaling and degree of infiltration, in addition to VO and US at baseline, 2, 4 and 8 weeks. At the end of the study, improvement rate was quicker in group A vs group B after 8 weeks of Cs therapy. All three parameters (TLS, VO and US) strongly correlated with one another. Skin thickness was the first parameter that improved, followed by TLS. In contrast, improvement in VO was delayed. Normalization rate of vascular pattern (assessed by VO) was low in both groups but higher in group A vs group B (46% vs 22%), despite virtually complete normalization by clinical and US assessment. In conclusion, while both TLS and US can be utilized in the evaluation of therapeutic efficacy in patients with plaque psoriasis, VO can provide information on vascular response to treatment, which may likely affect the duration of therapy and the relapse rates.

show abstract

mentioning

confidence: 99%

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Musumeci

Lacarrubba

et al. 2013

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

“…Patients with PND were categorized into two groups by NPT measured by US as NPT <20 mm (n=16) and NPT ≥20 mm (n=18) and the median NAPSI in two groups were 20.5 (12.2-33) and 28.5 (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), respectively (p= 0.05). There were 6 patients in type 1GS changes of psoriatic nails, 6 patients in type 2, 20 patients in type 3, and 2 patients in type 4.…”

Section: Ultrasound Findingsmentioning

confidence: 99%

“…US is also a non-invasive imaging method which allows viewing the anatomical and physiological details of the nails and provides information about the morphological appearance of the nail lesions, together with changes of the underlying tissue and blood flow alteration [22]. During the past decade, several studies have evaluated the usefulness of US for diagnosis, identification of disease activity and follow-up response to treatment in patients with psoriasis [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

Üreyen¹,

Kara²,

Ertürk³

et al. 2018

Med Ultrason

View full text Add to dashboard Cite

Objective: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs).Material and methods: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects. The nail plate thickness (NPT) was measured on gray scale using US. The NVRI was measured using color Doppler (CD) US. The measurements of the apical, arterial, venous limb diameters and morpho-structural changes (tortuous, cross-linked capillaries) were assessed using NVC.Results: Thirty-four patients with PND and 15 HCs were enrolled in this study. The two groups were matched for age and body mass index (BMI). Patients with PND had higher NPT and NVRI in comparison with HCs [(20 (17-23) vs 14 (14-15), p<0.001), (0.55 (0.51-0.61) vs 0.43 (0.38-0.49), p<0.001), respectively]. A higher proportion of patients with PND had tortuous capillaries than HCs (62% and 20% respectively, p=0.005). The mean NVRI was higher in patients with PND who had tortuous capillaries than patients who did not have tortuous capillaries (0.58 (0.7) and 0.52 (0.09), respectively p=0.033).Conclusion: Microvascular changes can be detected easily using non-invasive methods such as US and NVC. These methods can provide an objective data to better assess PND.

show abstract

“…As a result of increased keratinocyte proliferation in the epidermis and abnormal concentration of proinflammatory cells in the dermis, these two skin layers appear thicker than normal surrounding skin when using grey-scale ultrasound examination. When marked thickening of the epidermis occurs there may be seen a posterior acoustic shadowing artifact, that impedes/obstructs a clear assessment of the underlying dermis (fig 3) [19][20][21][22]. HFUS of a psoriatic plaque reveals a three-layer structure: a hyperechoic band that represents epidermal parakeratotic scaly superficial layer and suprapapillary epidermis, a non-echoic subepidermic band that corresponds to elongated epidermal rete ridges with congested and edematous loose connective tissue and, in the lower part, the reticular dermis appears as a hyperechoic band [19].…”

Section: Psoriatic Plaquementioning

confidence: 99%

“…A wide spectrum of dermal microvascular changes were reported: elongated, dilatated, and twisted capillary loops [19,29].…”

Section: Psoriatic Plaquementioning

confidence: 99%

Ultrasonography in psoriatic disease

et al. 2015

View full text Add to dashboard Cite

Psoriasis represents a common, chronic inflammatory disease involving the skin, nails and joints. Nail psoriasis in usually investigated and diagnosed by clinical examination. New insights support ultrasonography as being a non-invasive reliable imaging technique for studying nail and skin involvement in patients with psoriasis. Power Doppler frequency, higher than 10MHz enables a very sensitive detection and semiquantitative assessment of the blood flow at the dermal level and in the nail bed. In this review we will present the main US findings in skin and nail psoriasis, and discuss the importance of ultrasonography in diagnosing and monitoring psoriasis vulgaris.

show abstract

The use of high-frequency ultrasound as a method of assessing the severity of a plaque of psoriasis

Cited by 33 publications

References 0 publications

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

Ultrasonography in psoriatic disease

Contact Info

Product

Resources

About