The Use of Convalescent Plasma and Hyperimmunoglobulin in SARS-CoV-2 Infections

Gümral, Ramazan; Şahiner, Fatih

doi:10.46683/jmvi.2020.3

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“…13,15 A better understanding of infection pathology is important for regulating therapies (corticosteroids, anticoagulants, IL-1 and IL-6 blockers) that aim to prevent secondary and tertiary pathological changes, and thus reduce mortality and morbidity rates 7,8 and support specific antiviral treatments, including remdesivir, favipiravir, passive immunization, and recombinant monoclonal antibodies. 16 The aim of this study was to radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in SARS-CoV-2 infections.…”

Section: Introductionmentioning

confidence: 99%

Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis

et al. 2021

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Purpose To radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in COVID-19. Methods Between July 1 and August 31, 2020, consecutive patients diagnosed with COVID-19 were analyzed. Among these patients, those who underwent chest computed tomography (CT) examination at the time of presentation, patients with follow-up CT due to clinical deterioration were included in the study. The CTs of the patients were evaluated in terms of spleen size and volume. Results A total of 160 patients (88 females, 55%) were included in the study. The mean time between the initial and follow-up CT was 7.2 ± 2.8 days. The splenic volume (244.3 ± 136.7 vs. 303.5 ± 156.3 cm 3 ) and splenic index (421.2 ± 235.5 vs. 523.2 ± 269.4 cm 3 ) values were significantly higher in the follow-up CT compared to the initial CT (p < 0.001). The increase in the splenic volume and splenic index values was 59.2 ± 52.4 cm 3 and 101.9 ± 90.3 cm 3 (p < 0.001), respectively. The COVID-19 severity score was significantly higher in the follow-up CT compared to the initial CT (3.7 ± 4.2 vs. 12.5 ± 5.7, respectively; p < 0.001). The spleen width measured separately on the initial and follow-up CTs showed a highest positive correlation (r = 0.982, p < 0.001). Conclusion Our study indicates that spleen size increases slightly-moderately in the first stages of the infection, and this increase is correlated with the COVID-19 severity score calculated on the chest CT data, and in this respect, it is similar to infections presenting with cytokine storm.

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