RENAL transplantation (12 cadaveric and 4 living-related donors) was performed in 16 pediatric recipients (mean age 10.8 years) under FK 506 immunosuppression in combination with prednisone therapy. At a mean follow-up of 8.5 months, patient and graft survival rates are 100% and 94%, respectively. The only graft loss was due to recurrent hemolytic uremic syndrome (HUS) 4 days after transplantation. In the functioning grafts, the mean serum creatinine is 1.29 ± 0.38 mg/dL and the mean BUN is 26.0 ± 9.6 mg/dL. Seven patients are taking no prednisone, five are receiving 2.5 to 5 mg per day, and three are taking 10 to 15 mg per day.