The Use of Cadaver Kidneys for Transplantation in Young Children

So, Samuel; Gillingham, K.; Cook, Mary Jane; Mauer, S. Michael; Matas, A. J.; Nevins, Thomas E.; Chavers, Blanche M.; Najarian, J. S.

doi:10.1097/00007890-199012000-00016

Cited by 13 publications

(2 citation statements)

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“…Several studies in the pediatric population have demonstrated the efficacy of limiting steroid use in an effort to avoid steroid complications, particularly allowing improvement in catch-up growth. 1,2 The toxic effects of cyclosporine (CyA) in children are significant and include hirsutism (100%), hypertension (73%), fine tremor (34%), acute reversible nephrotoxicity (10%), and hyperuricemia with long-term CyA usage. 1,3 FK 506, a product of the fungus Streptomyces tsukubaensis, has a chemical structure and cytosolic binding sites different from CyA.…”

Section: Discussionmentioning

confidence: 99%

Pediatric renal transplantation under FK-506 immunosuppression

Jensen

Jordan²,

Schneck³

et al. 1993

Pediatr Nephrol

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RENAL transplantation (12 cadaveric and 4 living-related donors) was performed in 16 pediatric recipients (mean age 10.8 years) under FK 506 immunosuppression in combination with prednisone therapy. At a mean follow-up of 8.5 months, patient and graft survival rates are 100% and 94%, respectively. The only graft loss was due to recurrent hemolytic uremic syndrome (HUS) 4 days after transplantation. In the functioning grafts, the mean serum creatinine is 1.29 ± 0.38 mg/dL and the mean BUN is 26.0 ± 9.6 mg/dL. Seven patients are taking no prednisone, five are receiving 2.5 to 5 mg per day, and three are taking 10 to 15 mg per day.

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Section: Discussionmentioning

confidence: 99%

Pediatric renal transplantation under FK-506 immunosuppression

Jensen

Jordan²,

Schneck³

et al. 1993

Pediatr Nephrol

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show abstract

“…Serum calcium and phosphate levels should be monitored at regular intervals. Kidney transplantation has been successful in accelerating growth and prolonging survival (163). In view of the fact that the associated liver fibrosis is progressive and untreatable except by liver transplantation, kidney transplantation should be classified as high risk.…”

Section: Components That Require Managementmentioning

confidence: 99%