The use of buffered lignocaine solution in the presence of acute inflammation

Buffered 4% Articaine as a Primary Buccal Infiltration of the Mandibular First Molar: A Prospective, Randomized, Double-blind Study

“…The rationale is that the higher pH of buffered anesthetics (pH of 7.6 in the current study) is not as acidic as standard cartridges of lidocaine (pH of 4.8 in the current study), theoretically causing less pain during injection (7). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,16,21,22).…”

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,10,12,16,21,22). Buffering the formulation increased the pH of the anesthetic formulation (from 4.76-7.59) but did not result in less pain during solution deposition.…”

Buffered 4% Articaine as a Primary Buccal Infiltration of the Mandibular First Molar: A Prospective, Randomized, Double-blind Study

“…The rationale is that the higher pH of buffered anesthetics (pH of 7.6 in the current study) is not as acidic as standard cartridges of lidocaine (pH of 4.8 in the current study), theoretically causing less pain during injection (7). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,16,21,22).…”

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,10,12,16,21,22). Buffering the formulation increased the pH of the anesthetic formulation (from 4.76-7.59) but did not result in less pain during solution deposition.…”

The effect of adjusting the pH of local anaesthetics in dentistry: a systematic review and meta‐analysis

“…Shyamala et al (2016) indicated that the anaesthetic duration remains unchanged when the LA is buffered; conversely, Brennan et al (1987) affirmed that the duration is diminished. Rood (1977), Parirokh (2016), Saatchi et al (2015) and Schellenberg et al (2015) observed that alkalinization did not increase the anaesthetic success in the presence of acute inflammation, and Shurtz et al (2015) and Whitcomb et al (2010) did not find a significant benefit in normal tissues either. However, Saatchi et al (2016) reported that a buccal infiltration of sodium bicarbonate increased the success rate of inferior alveolar nerve block in the presence of pulpitis.…”

Efficacy of a Buffered 4% Lidocaine Formulation for Incision and Drainage: A Prospective, Randomized, Double-blind Study

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (12,13,(20)(21)(22), whereas others have not shown a decrease (1,2,14,16,23,24). Most of the previous medical and dental studies evaluated injections into healthy, noninflamed tissue sites.…”

“…Rood (2) performed maxillary tooth extractions on patients presenting with acute periodontitis and associated soft tissue inflammation using buffered and nonbuffered lignocaine. Rood concluded that both buffered and nonbuffered lignocaine solutions showed reduced efficacy in the presence of inflammation, and no significant difference was found between the 2 anesthetic formulations.…”

Buffered 4% Articaine as a Primary Buccal Infiltration of the Mandibular First Molar: A Prospective, Randomized, Double-blind Study

“…The rationale is that the higher pH of buffered anesthetics (pH of 7.6 in the current study) is not as acidic as standard cartridges of lidocaine (pH of 4.8 in the current study), theoretically causing less pain during injection (7). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,16,21,22).…”

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,10,12,16,21,22). Buffering the formulation increased the pH of the anesthetic formulation (from 4.76-7.59) but did not result in less pain during solution deposition.…”

The effect of adjusting the pH of local anaesthetics in dentistry: a systematic review and meta‐analysis

“…Shyamala et al (2016) indicated that the anaesthetic duration remains unchanged when the LA is buffered; conversely, Brennan et al (1987) affirmed that the duration is diminished. Rood (1977), Parirokh (2016), Saatchi et al (2015) and Schellenberg et al (2015) observed that alkalinization did not increase the anaesthetic success in the presence of acute inflammation, and Shurtz et al (2015) and Whitcomb et al (2010) did not find a significant benefit in normal tissues either. However, Saatchi et al (2016) reported that a buccal infiltration of sodium bicarbonate increased the success rate of inferior alveolar nerve block in the presence of pulpitis.…”

Efficacy of a Buffered 4% Lidocaine Formulation for Incision and Drainage: A Prospective, Randomized, Double-blind Study

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (12,13,(20)(21)(22), whereas others have not shown a decrease (1,2,14,16,23,24). Most of the previous medical and dental studies evaluated injections into healthy, noninflamed tissue sites.…”

“…Rood (2) performed maxillary tooth extractions on patients presenting with acute periodontitis and associated soft tissue inflammation using buffered and nonbuffered lignocaine. Rood concluded that both buffered and nonbuffered lignocaine solutions showed reduced efficacy in the presence of inflammation, and no significant difference was found between the 2 anesthetic formulations.…”

Buffered 4% Articaine as a Primary Buccal Infiltration of the Mandibular First Molar: A Prospective, Randomized, Double-blind Study

“…The rationale is that the higher pH of buffered anesthetics (pH of 7.6 in the current study) is not as acidic as standard cartridges of lidocaine (pH of 4.8 in the current study), theoretically causing less pain during injection (7). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,16,21,22).…”

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (8,9,13,15,20), whereas others have not shown a decrease (7,10,12,16,21,22). Buffering the formulation increased the pH of the anesthetic formulation (from 4.76-7.59) but did not result in less pain during solution deposition.…”

The effect of adjusting the pH of local anaesthetics in dentistry: a systematic review and meta‐analysis

“…Shyamala et al (2016) indicated that the anaesthetic duration remains unchanged when the LA is buffered; conversely, Brennan et al (1987) affirmed that the duration is diminished. Rood (1977), Parirokh (2016), Saatchi et al (2015) and Schellenberg et al (2015) observed that alkalinization did not increase the anaesthetic success in the presence of acute inflammation, and Shurtz et al (2015) and Whitcomb et al (2010) did not find a significant benefit in normal tissues either. However, Saatchi et al (2016) reported that a buccal infiltration of sodium bicarbonate increased the success rate of inferior alveolar nerve block in the presence of pulpitis.…”

Efficacy of a Buffered 4% Lidocaine Formulation for Incision and Drainage: A Prospective, Randomized, Double-blind Study

“…Systematic reviews in medicine have shown reduced injection pain with buffered anesthetics (17)(18)(19). In dentistry, some authors have shown decreased injection pain with buffered lidocaine (12,13,(20)(21)(22), whereas others have not shown a decrease (1,2,14,16,23,24). Most of the previous medical and dental studies evaluated injections into healthy, noninflamed tissue sites.…”

“…Rood (2) performed maxillary tooth extractions on patients presenting with acute periodontitis and associated soft tissue inflammation using buffered and nonbuffered lignocaine. Rood concluded that both buffered and nonbuffered lignocaine solutions showed reduced efficacy in the presence of inflammation, and no significant difference was found between the 2 anesthetic formulations.…”