The Use of a Water Extract from the Bark of Choerospondias Axillaris in the Treatment of Second Decree Burns

Nguyen, Duy-Lam; Nguyen, N. H.; Nguyen, Trung Thanh; Phan, Tong Son; Nguyen, V. D.; Grabe, Magnus; Johansson, R; Lindgren, Gunnar; Stjernström, Nils E.; Söderberg, Thor A.

doi:10.3109/02844319609056396

Cited by 17 publications

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“…Next, the finely ground powder of C. axill dried fruit was carefully sifted through a 40-mesh size sieve by hand. To extract the active compounds, the powder sample was subjected to a separate extraction proc Limited comprehensive studies have explored the antibacterial and xanthine oxidase inhibitory properties of C. axillaris fruit extract, despite claims of its antimicrobial and anti-inflammatory effects [31,[37][38][39]. This study aimed at the quantitative estimation of phytochemical contents and preliminary evaluation of the antioxidant, xanthine oxidase inhibitory, and antibacterial activities.…”

Section: Extraction Of C Axillaris Fruitsmentioning

confidence: 99%

“…In Vietnam, the bark is processed into an aqueous extract for topical application in treating burns and wounds [30]. In Laos and Vietnam, the fruit is used to enhance blood circulation and for wine production [31]. Scientific investigations have highlighted the pharmacological effects of C. axillaris fruit, including antioxidant [32] and anti-inflammatory properties [33], potential anti-tumor effects [34], cardioprotective activity [35,36], and anti-angiogenic properties [37].…”

Section: Introductionmentioning

confidence: 99%

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Total Phenolic and Flavonoid Contents, and Preliminary Antioxidant, Xanthine Oxidase Inhibitory and Antibacterial Activities of Fruits of Lapsi (Choerospondias axillaris Roxb.), an Underutilized Wild Fruit of Nepal

Neupane,

Bajracharya,

Thada

et al. 2023

Applied Sciences

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Choerospondias axillaris Roxb. (Anacardiaceae) is a deciduous tree, native to Nepal and the Himalayan region, that can reach a maximum height of 20 m. The study aimed to assess the total phenol, flavonoid, and carbohydrate content, and preliminary antioxidant potency, xanthine oxidase inhibition, and antibacterial properties of C. axillaris fruits extracts. Ethyl acetate, acetone, methanol, and water were used as extraction solvents. The quantitative analysis showed that the extracts had total polyphenols (68.28 μg to 154.91 μg gallic acid equivalent/mg extract), flavonoids (41.72 to 283.84 μg quercetin equivalent/mg extract), and carbohydrates contents (67.26 µg to 269.96 µg glucose equivalent/mg extract). The acetone extract exhibited the highest antioxidant activity (IC50: 15.72 µg/mL) and potent inhibition of xanthine oxidase (IC50: 20.80 µg/mL) among the extracts. The acetone extract exhibited the strongest antibacterial efficacy against Staphylococcus aureus and Bacillus cereus with inhibition zones of 13.76 mm and 12.56 mm, respectively. It also had the lowest minimum bactericidal concentration (MBC: 0.78 mg/mL) and minimum inhibitory concentration (MIC: 0.52 mg/mL) against S. aureus. In conclusion, the C. axillaris fruit extracts showed potent antioxidant, xanthine oxidase inhibitory, and antibacterial activities, suggesting their potential for pharmaceutical and nutraceutical applications. Further research should focus on the identification of active compounds and in vivo analysis of pharmacological activities.

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Section: Extraction Of C Axillaris Fruitsmentioning

confidence: 99%