The Uptake of Human Papillomavirus Vaccination and Its Associated Factors Among Adolescents: A Systematic Review

Abstract

Background: The purpose of this review was to explore the uptake of the human papillomavirus (HPV) vaccination, its associated factors, and the facilitators of and barriers to HPV vaccination among adolescents. Methods: A comprehensive literature search was conducted through 5 electronic databases, including PubMed, CINAHL, Cochrane Library, Medline, and PsycInfo from January 2006 to March 2015 for studies examining the uptake, awareness, knowledge, acceptability, and intention of adolescents with regard to HPV vaccination. Results: Twenty-eight studies were identified and included. The HPV vaccination uptake rate (at least 1 dose) varied significantly among countries, ranging from 2.4% to 94.4%. Scotland achieved the highest uptake of all the studies included in this review, while Hong Kong had the lowest, at 2.4% to 9.1%. This review also showed that adolescents had limited awareness and knowledge of HPV infections and vaccines, even 10 years after the vaccine had become available. Conclusions: It is recommended that barriers to the uptake of the vaccine should be addressed, and that school-based sexual health education of HPV infection and vaccine promotion should be reinforced.

Determinants of Meningococcal ACWY vaccination in adolescents in the US: completion and compliance with the CDC recommendations

“…The extent to which individual-level determinants including demographics, clinical or provider characteristics, state of residence, and vaccine mandates, as well as state-level determinants such as the number of pediatricians per 10,000 persons aged 0-18 years, state health-care expenditures, education mandates and IIS utilization, were associated with the likelihood of MenACWY vaccination was assessed to further investigate potential determinants of these differences in completion and compliance. While other studies have assessed determinants of vaccination in adolescents, 26,27 to our knowledge, this is the first study to investigate MenACWY vaccine primary and booster dose completion and compliance with ACIP recommendation using multi-level modeling to determine the impact of state-level factors in addition to individual-level factors.…”

Factors associated with hindering the acceptance of HPV vaccination among caregivers - A cross-sectional study in Argentina

“…People´s intention to vaccinate against HPV is a factor that contributes to the acceptance of the vaccine. Thus, many studies have been carried out to research the determinants of HPV vaccine acceptance [10][11][12][13]. In this sense, the fact that HPV vaccines are aimed at adolescents raises the following issues: a) there may be important barriers to access preventive health services for this population subgroup, and b) caregivers opinions affect adolescents' vaccination.…”

“…In this sense, the fact that HPV vaccines are aimed at adolescents raises the following issues: a) there may be important barriers to access preventive health services for this population subgroup, and b) caregivers opinions affect adolescents' vaccination. The studies on this subject have been carried out in high-income countries, where potentially associated factors such as perception of risk, awareness and knowledge of HPV, and recommendation source, among others, have been assessed [13]. Latin America countries such as Colombia, Mexico, and Brazil have studied HPV vaccine acceptability, finding that it varied depending on the social context characteristics and that knowledge of the HPV vaccine was an important determinant for its acceptability [14][15][16].…”

Explaining the determinants of Human Papillomavirus Vaccine uptake and Strategies to Increase Its Uptake among young adults in Capital of Iran: a qualitative study

“…This may be due to a person's unwillingness to be aware of the disease and its vaccine, on the other hand, due to the culture and values of the society where talking about sex is thought taboo. Many studies have also reported that lack of HPV vaccine uptake is due to a lack of knowledge about the vaccine and related cancer in men and women [28][29][30][31].…”