The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Lo, Pui‐Chi; Rodríguez‐Morgade, M. Salomé; Pandey, Ravindra K.; Ng, Dennis K. P.; Torres, Tomás; Dumoulin, Fabienne

doi:10.1039/c9cs00129h

Cited by 546 publications

(337 citation statements)

References 53 publications

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“…443,444 As shown in Fig. 70A, PDT relies on a nontoxic photosensitizer (PS), e.g., porphyrin, 445 phthalocyanine, 446 BODIPY, 447 and cyanine, 448 to induce the formation of reactive oxygen species (ROS) under specic wavelengths of light, leading to cytotoxicity. 449 According to the photochemical mechanism of ROS generation (Fig.…”

Section: Principle Of Chemotherapeutic Drug Deliverymentioning

confidence: 99%

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

et al. 2020

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Section: Principle Of Chemotherapeutic Drug Deliverymentioning

confidence: 99%

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

et al. 2020

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“…Phthalocyanine was proposed as the photosensitizing agent for ROS production attached to SWCNH through hydrophobic π–π stacking interactions [ 52 ]. Phthalocyanine is another promising compound with outstanding properties for PDT [ 106 ]. SWCNH functionalized with phycocyanin also resulted efficiently for ROS production and PTT in both in vitro (in 4T1 triple negative breast cancer cells) and in vivo (in mice with subcutaneous 4T1 cell tumor formation).…”

Section: Swcnh In Cancer Therapymentioning

confidence: 99%

Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

2020

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Cancer has become one of the most prevalent diseases worldwide, with increasing incidence in recent years. Current pharmacological strategies are not tissue-specific therapies, which hampers their efficacy and results in toxicity in healthy organs. Carbon-based nanomaterials have emerged as promising nanoplatforms for the development of targeted delivery systems to treat diseased cells. Single-walled carbon nanohorns (SWCNH) are graphene-based horn-shaped nanostructure aggregates with a multitude of versatile features to be considered as suitable nanosystems for targeted drug delivery. They can be easily synthetized and functionalized to acquire the desired physicochemical characteristics, and no toxicological effects have been reported in vivo followed by their administration. This review focuses on the use of SWCNH as drug delivery systems for cancer therapy. Their main applications include their capacity to act as anticancer agents, their use as drug delivery systems for chemotherapeutics, photothermal and photodynamic therapy, gene therapy, and immunosensing. The structure, synthesis, and covalent and non-covalent functionalization of these nanoparticles is also discussed. Although SWCNH are in early preclinical research yet, these nanotube-derived nanostructures demonstrate an interesting versatility pointing them out as promising forthcoming drug delivery systems to target and treat cancer cells.

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“…Fluorous phthalocyanines and subphthalocyanines have attracted our interest as a result of their applications in organic field-effect transistors [16], organic light-emitting diodes [17], photovoltaics [18], nonlinear optical materials [19], and photodynamic therapy [20]. To date there are limited reports describing the properties of phthalocyanines and subphthalocyanines in the fluorous phase [21,22].…”

Section: Introductionmentioning

confidence: 99%

Fluorous phthalocyanines and subphthalocyanines

Yoshinaga

Delage-Laurin

Swager

2020

J. Porphyrins Phthalocyanines

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Incorporating fluorine atoms into a molecule can endow it with various unique properties that enable materials applications. Selective solubility in fluorous solvents is achieved by a high fluorine content and selective partitioning into perfluorinated liquids over organic and aqueous phases provides orthogonal opportunities for chemistry and materials assembly. Although there is a growing number of partially fluorinated molecules, there are insufficient structural design principles to produce diverse fluorous soluble dyes. Herein, we report the synthesis of six fluorous phthalocyanine and subphthalocyanine dyes, and study their properties in the fluorous phase. Phthalocyanines generally display limited solubility and we also observed apparent aggregation in the fluorous phase. However, the nonplanar subphthalocyanines showed greater solubility. Subphthalocyanines also displayed fluorescence in selected solvents, and their emissive properties were investigated. The materials described expand the library of fluorous dyes and provide insights for the design of new molecules with fluorous solubility.

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The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Abstract: Due to their photoproperties and easy chemical functionalisations, phthalocyanines are amongst the most promising advanced photosensitisers for photodynamic therapy of cancer.

Cited by 546 publications

References 53 publications

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer

Fluorous phthalocyanines and subphthalocyanines

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