The Unique Carboxymethyl Fenugreek Gum Gel Loaded Itraconazole Self-Emulsifying Nanovesicles for Topical Onychomycosis Treatment

Alqahtani, Ali; Raut, Bhavana; Khan, Shagufta; Mohamed, Jamal Moideen Muthu; Fatease, Adel Al; Alqahtani, Taha; Alamri, Ali H.; Ahmad, Fazil; Venkatesan, Krishnaraju

doi:10.3390/polym14020325

Cited by 26 publications

(14 citation statements)

References 37 publications

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“…CRL lipophilicity (log P = 3.8) can be attributed to these low percent EE values, allowing it to be efficiently integrated into PVP/SDS dual carriers in the prepared formulations. According to Alqahtani et al, a lipophilic drug might enhance EE by employing lipid as an encapsulating carrier [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…CRL lipophilicity (log P = 3:8) can be attributed to these low percent EE values, allowing it to be efficiently integrated into PVP/SDS dual carriers in the prepared formulations. According to Alqahtani et al, a lipophilic drug might enhance EE by employing lipid as an encapsulating carrier [24]. The PS was found to be larger for batches DF3 and DF6 because viscosity of 2% w/v KGM used in their formulation was appreciably high, which could have affected appropriate diffusion of glutaraldehyde in KGM phase for cross-linking.…”

Section: Ee (%)mentioning

confidence: 99%

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Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone

Mohamed¹,

Mahajan

El-Sherbiny

et al. 2022

BioMed Research International

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The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64 (KVA64), and glutaraldehyde to ameliorate stomach specific floating microspheres (SSFM) using domperidone (DoN) to increase in vivo bioavailability and emerging health pathologies. The SSFM were made using the emulsion cross-linking process, and the polymer was chosen based on its ability to get cross-linked. The thermodynamic parameters were used to determine the AL classes of phase solubility curves using ideal complexes produced with KVA64. The optimal interaction constants at 25 and 37°C were found to be 116.14 and 128.05 M-1, respectively. The prepared SSFM had an average particle size (PS) of 163.71 ± 2.26 mm and a drug content of 96.66 ± 0.32 %. It can be determined from in vitro drug release experiments that drug release is good in terms of regulated drug release after 12 h ( 92.62 ± 2.43 %). The SSFMs were approximately sphere-shaped and had smooth surfaces, according to the morphological data. SSFMs were investigated using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and differential scanning calorimetry (DSC), and no chemical structural changes were identified. The SSFMs produces a considerable gastric residence time with optimal DoN release and absorption in stomach fluid, and the mean residence time ( 17.36 ± 1.4 h) and t 1 / 2 ( 10.47 ± 0.6 h) were considerably longer ( p < 0.05 ) than those obtained following i.v. treatment ( MRT = 8.42 ± 1.2 h; t 1 / 2 = 9.07 ± 0.7 h). The SSFMs maintained good physical stability for three months when stored at room temperature.

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Section: Resultsmentioning

confidence: 99%

Section: Ee (%)mentioning

confidence: 99%

Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone

Mohamed¹,

Mahajan

El-Sherbiny

et al. 2022

BioMed Research International

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“…Beller's ointment base, Simple ointment base, oleaginous ointment base, Paraffin ointment base (absorption base) formulations (F7, F8, F9, and F10) showed opaque nature, creamy yellowish color and greasy on application. Emulsifying ointment base showed opaque, off white and greasy on application [9].…”

Section: Evaluation Of Semi-solid Preparationsmentioning

confidence: 97%

Comparative Study of Semi-Solid Bases of Naproxen: Pharmaceutical Technology Aspects

SRIVIDYA¹,

NACHIYA

Ebrahim

et al. 2022

Int J App Pharm

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Objective: The main objectives of the present investigation work included that the preparation of a suitable naproxen semi-solid dosage form by using different types of semi-solid bases (gel bases, ointment bases) for topical application for the effective treatment of muscle aches. Methods: Different types of semi-solid bases (gel bases and ointment bases) were successfully prepared by the incorporation method to know the effect of semi-solid bases on drug release from topical semi-solid formulations. In all formulations, the drug was added by the levigation method. An evaluation study of prepared formulations, includes physical appearance, spreadability, extrudability, pH was conducted according to official methods. Results: Percent drug release of all formulations was conducted by taking diffusion cells with cellophane membrane and results showed that gel-based formulations showed more drug release than ointment-based formulations. Carbopol gel base (F1) showed more drug release (98.76 %), simple ointment base formulation (F8) showed least drug release (25.11%). From the stability studies reports at various temperature and humidity conditions it is evident that all formulations are stable for one month. In all the formulations, the drug content was observed at 95.75%. Conclusion: Finally concluded that the NXN topical dosage forms can be prepared by using gel-type bases preferably than ointment bases to release more drug from formulations.

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“…It is a flowering plants species of family Lamiaceae, native to the Mediterranean, Arabian Peninsula, and Atlantic islands. It grows to 60 cm tall, with grey-green leaves, which are lance or linear-shaped with lightly woolly texture and toothed edges [6]. It blooms in late spring and has purple flowers with pale violet bracts on top.…”

Section: Lavandula Dentatamentioning

confidence: 99%

Ethnopharmacological and Phytochemical Study of Major Species From Labiatae Family in Saudi Arabia: A Systematic Review

Ahmad

KAMARAJ

MOHAMED³

et al. 2022

Int J App Pharm

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A review on a medicinal plant belong to family Labiatae has been made in the Kingdom of Saudi Arabia. Among the reported flora in the Kingdom of Saudi Arabia, Labiatae family has the highest species. A total of 23 species of Labiatae family has been reported with high medicinal value. A detail review on 12 species of Labiatae family had done to know their phytochemical constituents, medicinal uses and pharmacological properties. In this review we also explore the total chemical constituents present in each plant with a unique list of 3D chemical structures. (E)-2-Hexenal, 1,8-Cineole, Bicyclogermacrene, Borneol, Bornyl acetate, Bulnesol, Caffeic acid, Camphene, Camphor, Eugenol, Gallic acid, Quercetin, Terpinene, Thymol, etc are the important constituent in these 12 species of Labiatae family. This study also shows that Marrubium vulgare L, Ocimum basilicum L, Origanum majorana and Otostegia fruticosa plants had reported with many medicinal uses and pharmacological properties. Medicinal constituents include the highest phenolic, flavonoid content and strong aromatic essential oil. Further scientific investigations on these 12 species are needed to explore toxicity and clinical efficacy and as well as to explore the therapeutic effects of major secondary metabolites. The summarized information from the current review may be a useful tool for researchers to carry out further study and explore other scientific aspects of the herbs.

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The Unique Carboxymethyl Fenugreek Gum Gel Loaded Itraconazole Self-Emulsifying Nanovesicles for Topical Onychomycosis Treatment

Cited by 26 publications

References 37 publications

Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone

Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone

Comparative Study of Semi-Solid Bases of Naproxen: Pharmaceutical Technology Aspects

Ethnopharmacological and Phytochemical Study of Major Species From Labiatae Family in Saudi Arabia: A Systematic Review

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