The ubiquitous role of mitochondria in Parkinson and other neurodegenerative diseases

Compartmentalized Signaling in Aging and Neurodegeneration

“…Mitochondria are highly dynamic and undergo continue cycles of fusion and fission, that are important for their metabolic activity but also for their transportation to or from synapses [ 43 , 44 ]. In recent years, therefore, it has become clear how perturbations in mitochondrial dynamics contribute to the aetiology of NDs [ 45 ], including AD [ 46 ] and PD [ 47 ].…”

Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson’s Disease

“…Both are mediators of mitophagy and a loss of function of Parkin and/or PINK1 may cause an accumulation of dysfunctional mitochondria leading to early onset-PD [65]. In general, three main abnormal mitochondrial processes involved in the development of neurodegeneration have been supposed, namely, impaired mitochondrial (1) dynamics (i.e., fusion and fission), ( 2) kinetics (i.e., transport and distribution) and (3) bioenergetics of the electron transport chain and TCA (tricarboxylic acid) cycle [66]. Since 1980, many different research groups evaluated alterations in mitochondria in the context of PD on DNA as well as protein levels in humans, cell culture as well as animal models using different approaches and techniques, including proteomics [67][68][69][70][71][72][73][74][75][76].…”

Modeling brain disorders using neuroinformatics in cellular physiology

“…Some of the statements and remarks in Chapter 1 were published in Advances in Experimental Medicine and Biology (book series, Springer 2016) Theocharopoulou et al (2017a) and in the proceedings of "IEEE International Symposium on Signal Processing and Information Technology (ISSPIT)" in 2015 (Theocharopoulou et al, 2015a). Another part has been accepted for publication in scientific journal AIMS Neuroscience, AIMS press (Theocharopoulou, 2020). Some parts of Chapter 2 were published in Advances in Experimental Medicine and Biology (book series, Springer 2015) and in Genetics and Neurodegeneration proceedings of 2nd World Congress on "Genetics, Geriatrics and Neurodegenerative Diseases Research 2016" (Theocharopoulou andVlamos, 2015, Theocharopoulou et al, 2017b) and also in book of the refereed proceedings of the 9th International Conference on Artificial Intelligence Applications and Innovations, AIAI 2013 .…”

“…Another part has been accepted for publication in scientific journal AIMS Neuroscience, AIMS press (Theocharopoulou, 2020). Some parts of Chapter 2 were published in Advances in Experimental Medicine and Biology (book series, Springer 2015) and in Genetics and Neurodegeneration proceedings of 2nd World Congress on "Genetics, Geriatrics and Neurodegenerative Diseases Research 2016" (Theocharopoulou andVlamos, 2015, Theocharopoulou et al, 2017b) and also in book of the refereed proceedings of the 9th International Conference on Artificial Intelligence Applications and Innovations, AIAI 2013 . Another part has been accepted to be published in Advances in Experimental Medicine and Biology (book series, Springer 2020) (Theocharopoulou and Vlamos, 2020).…”

“…Most of the results reported in this dissertation have already been published in respectful peer-reviewed journals and have been presented in international conferences (followed up by v a paper publication in the conference proceedings) , Theocharopoulou and Vlamos, 2015, Theocharopoulou et al, 2015a,b, Giannakis et al, 2016, Theocharopoulou and Bobori, 2016, Kapodistrias et al, 2017, Theocharopoulou et al, 2017b,a, Theocharopoulou and Vlamos, 2020, Theocharopoulou, 2020. Publications in (Theocharopoulou et al, 2017a, 2015a, Kapodistrias et al, 2017 were co-authored with Bobori, Catherine, Avramouli, Antigoni and Kapodistrias, Nikolaos, respectively.…”