Abstract. The ubiquitous eps15 protein was initially described as a substrate of the EGF receptor kinase. Its functions are not yet delineated and this work provides evidence for its possible role in endocytosis. A novel anti-epsl5 antibody, 6G4, coimmunoprecipitated proteins of molecular mass 102 kD. In human cells, these proteins were identified as the ~-and [3-adaptins of the AP-2 complex on the basis of their NH2-terminal sequence and their immunoreactivity with anti-a-and anti-13-adaptin antibodies but n…
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