2009
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Abstract: beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is a membrane-bound protease that is essential for the production of beta-amyloid protein (Abeta). Given the crucial role of Abeta accumulation in Alzheimer's disease (AD), inhibition of BACE1 activity may represent a feasible therapeutic strategy in the treatment of AD. Recently, we and others identified reticulon 3 (RTN3) and reticulon 4-B/C (RTN4-B/C or Nogo-B/C) as membrane proteins that interact with BACE1 and inhibit its ability to produ… Show more

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“…Consistently, transgenic mice overexpressing RTN3 develop dystrophic neuritis that are morphologically similar to those observed in AD brains and that correlate with the formation of RTN3 aggregates in susceptible brain regions (Hu et al 2007). However, these findings are in conflict with those by Kume et al (2009a, b), in which, although reporting that RTN3 subcellularly co-localizes with BACE1, no significant differences in its expression levels were observed between control and AD brains.…”
Section: The Role Of Rtns In the Pathological Processes Of Neurodegencontrasting
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“…Consistently, transgenic mice overexpressing RTN3 develop dystrophic neuritis that are morphologically similar to those observed in AD brains and that correlate with the formation of RTN3 aggregates in susceptible brain regions (Hu et al 2007). However, these findings are in conflict with those by Kume et al (2009a, b), in which, although reporting that RTN3 subcellularly co-localizes with BACE1, no significant differences in its expression levels were observed between control and AD brains.…”
Section: The Role Of Rtns In the Pathological Processes Of Neurodegencontrasting
“…Notably, in a subtractive hybridization screening, human RTN3 was found to be downregulated in the temporal lobes of AD patients (Yokota et al 2006). Although the two-transmembrane-domain tertiary structure of RTN3 and RTN4 seems to critically affect BACE1 enzymatic activity (Kume et al 2009a, b), the relevance of these RTNs for AD pathology and their exact role remains controversial and thus yet to be established. On the one hand, a mechanism by which RTN3 may function as a negative modulator of Aβ production has been proposed and is such that the association of RTN3–BACE1 may alter its trafficking itinerary, thus affecting BACE1 enzymatic activity more markedly in post-Golgi compartments like the endosomes (Small and Gandy 2006; Shi et al 2009).…”
Section: The Role Of Rtns In the Pathological Processes Of Neurodegenmentioning
“…Altered expression levels of RTNs are found in a variety of disease states, including neurological disorders (Yan et al, 2006;Fergani et al, 2005;Bandtlow et al, 2004). We and others have demonstrated that RTNs interact with BACE1 and negatively modulate BACE1 protease activity (He et al, 2004;He et al, 2006;Murayama et al, 2006;Wojcik et al, 2007;Kume et al, 2009). In the present study, we further demonstrated that increased expression of RTN3 in our mouse models significantly reduced Aβ production, amyloid deposition and plaque load.…”
Section: Discussionmentioning
“…BACE1 interacts with RTNs on the membrane in a region near their C-terminal sequences (33,34). Increased expression of RTNs significantly reduces the production of A␤ in both cultured cells and transgenic mouse models (23,(35)(36)(37)(38).…”
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