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Cited by 25 publications
(15 citation statements)
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“…mTOR activity can also be affected by complex I; [ 15 ] and the Akt/mTOR signaling pathway is an upstream regulator of proliferation, EMT and cancer metastasis. [ 23 27 ] Therefore, we investigated if the Akt/mTOR signaling pathway is activated by loss of NDUFB9 in MDA-MB-231 cells. Down-regulation of NDUFB9 markedly enhanced the phosphorylation of Akt (S129), mTOR (S2448) and p70S6K in MDA-MB-231 cells ( Fig 5C and 5F ).…”
Section: Resultsmentioning
confidence: 99%
“…mTOR activity can also be affected by complex I; [ 15 ] and the Akt/mTOR signaling pathway is an upstream regulator of proliferation, EMT and cancer metastasis. [ 23 27 ] Therefore, we investigated if the Akt/mTOR signaling pathway is activated by loss of NDUFB9 in MDA-MB-231 cells. Down-regulation of NDUFB9 markedly enhanced the phosphorylation of Akt (S129), mTOR (S2448) and p70S6K in MDA-MB-231 cells ( Fig 5C and 5F ).…”
Section: Resultsmentioning
confidence: 99%
“…The Akt pathway plays critical roles in regulation of apoptosis [14,15], which leads to expansion of cells and accumulation of genetic mutations [16,17], and therefore constitutes one of the key mechanisms in progression of cancers. The Akt signaling pathway was also demonstrated to play diverse roles in cancer development [18,19] through angiogenesis [20], cell growth [21], mesenchymal transition [22], and cell apoptosis and death [23]. In this context, regulation of proliferation and migration of NSCLC cells by isoflurane could be explained at least in part by modulation of the Akt-mTOR signaling pathway.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, it was widely reported that a single gene can inhibit CRC. For instance, MIER3 [ 14 ], LASP2 [ 15 ], SIRT1 [ 16 ], and LZTS1 [ 17 ] genes can inhibit the development of CRC. Because the neoplasm develops through a complex process, it cannot be completely elucidated by understanding the changes in a single gene; therefore, the aims of this study are as follows: to elucidate the molecular mechanism of the development of CRC in the midst of each stage generally, and to analyze the links among signal control network during each stage.…”
Section: Introductionmentioning
confidence: 99%