2006
DOI: 10.1007/s00280-005-0183-4 View full text |Buy / Rent full text
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Abstract: The data suggested that dihydronitidine toxicity targeted a particular intracellular organelle in the tumor cells.

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“…Benzo[c]phenanthridine alkaloids have been isolated from the stem of the plant: nitidine and dihydronitidine revealed specific cytotoxicity against A-549 cells in vitro (Iwasaki et al, 2006). Moreover, nitidine has also been shown to inhibit tumour growth in lung adenocarcinoma bearing mice (xenograft model) (Iwasaki et al, 2006(Iwasaki et al, , 2010. As the MeOH leaf extract did not show any cytotoxicity against either of the cancer cell lines tested here, this suggests that the extract does not contain these alkaloids.…”
Section: Discussionmentioning
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“…Benzo[c]phenanthridine alkaloids have been isolated from the stem of the plant: nitidine and dihydronitidine revealed specific cytotoxicity against A-549 cells in vitro (Iwasaki et al, 2006). Moreover, nitidine has also been shown to inhibit tumour growth in lung adenocarcinoma bearing mice (xenograft model) (Iwasaki et al, 2006(Iwasaki et al, , 2010. As the MeOH leaf extract did not show any cytotoxicity against either of the cancer cell lines tested here, this suggests that the extract does not contain these alkaloids.…”
Section: Discussionmentioning
“…Several compounds found in the oil could also be present in the DCM extract and could in part be responsible for the activity found, although, according to Hao et al (2004), alkaloids also display anti-inflammatory and analgesic effects. Benzo[c]phenanthridine alkaloids have been isolated from the stem of the plant: nitidine and dihydronitidine revealed specific cytotoxicity against A-549 cells in vitro (Iwasaki et al, 2006). Moreover, nitidine has also been shown to inhibit tumour growth in lung adenocarcinoma bearing mice (xenograft model) (Iwasaki et al, 2006(Iwasaki et al, , 2010.…”
Section: Discussionmentioning
“…Dihydronitidine Anticancer Induced apoptosis via regulating the expression of cyclin-dependent kinase 2 and cyclin E family genes and up-regulating the cell death related genes [122] . Sparteine Antiarrhythmic Inhibited Na+ and K+ channels [123] .…”
Section: Anticancermentioning
“…Bioassay-directed fractionation of T. asiatica extract was studied and found that nitidine inhibited human lymphoblastoid cell killing by HIV-1 in vitro XTTbased anti-HIV assay [5,6]. Ethanolic extract of dried stem chips was studied for in vitro cytotoxicity on various cell lines using Fluorescence activated cell sorter analysis and measurement of Caspase-3 activity and found that dihydronitidine isolated from this extract had highly specific cytotoxicities to human lung carcinoma (A549) cells and induced specific apoptotic cell death by regulating the cell cycle related genes (CDK2; CCNE) [7].…”
Section: Introductionmentioning