The true cause of pyloric stenosis is hyperacidity

Rogers, Ian Munro

doi:10.1111/j.1651-2227.2006.tb02197.x

Cited by 20 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pathogenesis of IHPS is multifactorial and includes hypergastrinemia, abnormal pyloric innervation, genetic mutations, and environmental influences [5] [14]. This study was performed in Nordrhein-Westfalen (NRW).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiology of Hypertrophic Pyloric Stenosis Revisited: The Use of Isotonic Fluid for Preoperative Infusion Therapy Is Supported

Troebs¹

2014

OJPed

View full text Add to dashboard Cite

Background: The aim of this study was to elucidate the preoperative clinical and biochemical profile of infants with IHPS to optimize infusion therapy. Patients and Method: We retrospectively analyzed data from 56 infants who were operated for IHPS. Our study includes growth and laboratory data prior to the initiation of therapy. Results: Median duration of propulsive vomiting was 4 d; the median age was 37 d (18 -108), and the median body weight was 3840 g (2760 -5900). Metabolic alkalosis (MAlk) with a pH of 7.45 ± 0.06 and an st 3 HCO − of 28.7 ± 4.5 mmol/l was found. In a subgroup of the infants, negative base excess (BE) was observed. The sodium concentration was normal or reduced (mean/median of 137 mmol/l). There was a strong negative correlation between st 3 HCO − and K + . The carbon dioxide partial pressure tended to increase (5.72 ± 0.84 kPa). Calculations of osmolality revealed a normal osmolarity. Hypoglycemia did not occur. The creatinine clearance according to the Schwartz formula remained at a normal level (85.3 ± 24.3 ml/min/ 1.73 m 2 ). Discussion: The presented case series is characterized by a short duration of preoperative vomiting. MAlk can be classified as a chloride deficiency syndrome. It is accompanied by normo-or hyponatremic dehydration with normal osmolality. Partial respiratory compensation occurred. A normal creatinine clearance indicated good glomerular renal function. Conclusion: The presented study supports the use of an isotonic infusion fluid with a low glucose concentration for preoperative infusion therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of the pylorus tumor remains enigmatic. There is good evidence that the inherited hyperacidity caused by an immature feedback mechanism in gastric production is the predominant factor [5]. However, whether the elevation of serum gastrin is a primary or secondary phenomenon remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Pathophysiology of Hypertrophic Pyloric Stenosis Revisited: The Use of Isotonic Fluid for Preoperative Infusion Therapy Is Supported

Troebs¹

2014

OJPed

View full text Add to dashboard Cite

show abstract

“…Exposure to macrolides has been linked and is considered a possible risk factor in the development of HPS [76]. Other researchers have suggested that growth factors, such as hormones and peptides [77,78], or gastric acid hypersecretion may play a role [79].…”

Section: Hypertrophic Pyloric Stenosis Pathophysiologymentioning

confidence: 99%

Essential Diagnosis of Abdominal Emergencies in the First Year of Life

Louie

2007

Emergency Medicine Clinics of North America

View full text Add to dashboard Cite

“…IHPS are the common leading etiology for the nonbilious emesis requiring a pediatric surgical intervention [6]. The peak age of presentation in an infant is between 3 to 6 weeks of age [7]. Reports also have described early and late presentation of 2 to 8 weeks of age, respectively.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Value in the Early Diagnosis and Exclusion of Idiopathic Hypertrophic Pyloric Stenosis: 10 Years Experience at Babylon Governorate

Resheed¹

2017

J Gen Pract

View full text Add to dashboard Cite

Background: Idiopathic Hypertrophic Pyloric Stenosis (IHPS) is one of the most common surgical conditions of early infancy, presenting in 1.5 to 4 per 1000 live births. Despite this high prevalence, the precise etiology remains poorly understood. The diagnosis is made primarily with history and physical examination. Projectile, non-bilious vomiting is the classic presentation of an infant with IHPS. The typical physical exam findings include visible peristaltic waves and palpation of the olive mass in the upper abdomen. In the absence of a palpable mass, an upper gastrointestinal (UGI) barium study or ultrasonographic evaluation will usually make the diagnosis. Ultrasound is the preferred modality to diagnose IHPS. Demonstration of pyloric muscle thickness of 3.5 mm to 4 mm or more and pyloric channel length of 16 mm or more increases the specificity of the ultrasound to 100%.

show abstract

The true cause of pyloric stenosis is hyperacidity

Abstract: Persisting duodenal hyperacidity is created by an inherited high PCM and loss of gastrin control. These two factors produce pyloric stenosis through work hypertrophy from repeated pyloric contraction in response to hyperacidity.

Cited by 20 publications

References 37 publications

Pathophysiology of Hypertrophic Pyloric Stenosis Revisited: The Use of Isotonic Fluid for Preoperative Infusion Therapy Is Supported

Pathophysiology of Hypertrophic Pyloric Stenosis Revisited: The Use of Isotonic Fluid for Preoperative Infusion Therapy Is Supported

Essential Diagnosis of Abdominal Emergencies in the First Year of Life

Ultrasound Value in the Early Diagnosis and Exclusion of Idiopathic Hypertrophic Pyloric Stenosis: 10 Years Experience at Babylon Governorate

Contact Info

Product

Resources

About