The Treatment of Syphilis with Antibiotics Other Than Penicillin

Olansky, S; Garson, Warfield

doi:10.1001/archderm.1958.01560060014003

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…Chloramphenicol. The early literature concluded that chloramphenicol was as effective as tetracycline in all stages of syphilis, with the advantage of few or no gastrointestinal side effects (247). However, the blood dyscrasias later reported led to its removal as an alternate therapy for syphilis (247).…”

Section: Early Syphilis (Primary Secondary and Early Latent)mentioning

confidence: 99%

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

1999

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SUMMARY Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described in 1905, but because of the inability to culture the organism and the limitations of direct microscopy, serologic testing is the mainstay of laboratory diagnosis. The disease has been arbitrarily divided into several stages. The primary stage is defined by a chancre at the site of inoculation. The secondary stage is characterized by a polymorphic rash, lymphadenopathy, and other systemic manifestations. A variable asymptomatic latent period follows, which for epidemiologic purposes is divided into early (<1 year) and late (>1 year) stages. The early stages (primary, secondary, and early latent) are potentially infectious. The tertiary stage is the most destructive and is marked by cardiovascular and neurologic sequelae and gummatous involvement of any organ system. Congenital infection may result in protean early or late manifestations. Unlike many other bacteria causing infectious diseases, the organism remains sensitive to penicillin, and this remains the mainstay of therapy.

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Section: Early Syphilis (Primary Secondary and Early Latent)mentioning

confidence: 99%

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

1999

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“…Penicillin is undoubtedly superior, but chlortetracycline, chloramphenicol, oxytetracycline, and also tetracycline are effective, as are carbomycin (Magnamycin) and erythromycin (Montgomery and Knox, 1959a;Buckinger, Hookings, and Garson, 1955). T. pallidum is reported to be more sensitive to erythromycin and carbomycin than to other antibiotics except penicillin (Thomas, 1959), but because the tetracyclines have been available longer, there is a greater experience with their use, and also to a lesser extent with that of chloramphenicol (King, 1959;Olansky and Garson, 1958). Streptomycin is only weakly active (Willcox, 1950a).…”

Section: Antibiotics Other Than Penicillinmentioning

confidence: 99%