The Treatment of Solar Lentigo using Dr. Hoon Hur's Optimal Melanocytic Suicide-2 Parameter with a High fluence 1064nm Nd:YAG Laser without Postinflammatory Hyperpigmentation

The Treatment of Hori's Nevus by New Combination Treatment without Side Effects: Dr. Hoon Hur's Golden Parameter Therapy and Dr. Hoon Hur's Optimal Melanocytic Suicide-2 Parameter Therapy

“…Although the exact causes of PIH are still unknown, some reasons are thought to be the possible causes of PIH occurrence when using traditional laser therapy in Hori's nevus [10][11][12][13]. The 532 nm wavelength of Q-Swithched Nd:YAG laser, 694 nm wavelength of ruby laser, 755 nm wavelength of alexandrite laser and 515-755 nm wavelength of intense pulsed light are generally absorbed by much more melanin than 1064 nm wavelength of Q-Swithched Nd:YAG laser [13][14][15][16][17]. This higher absorbance to the melanin creates a laser energy that destroys epidermal melanocytes which also injuries the surrounding keratinocytes of the lesion [13][14][15][16][17].…”

“…The 532 nm wavelength of Q-Swithched Nd:YAG laser, 694 nm wavelength of ruby laser, 755 nm wavelength of alexandrite laser and 515-755 nm wavelength of intense pulsed light are generally absorbed by much more melanin than 1064 nm wavelength of Q-Swithched Nd:YAG laser [13][14][15][16][17]. This higher absorbance to the melanin creates a laser energy that destroys epidermal melanocytes which also injuries the surrounding keratinocytes of the lesion [13][14][15][16][17]. These damaged keratinocytes secrete interleukin-1 (IL-1), which stimulates keratinocytes to secrete some keratinocytic injury-induced cytokines, which are endothelin-1, α-Melanocyte Stimulating Hormone (MSH), Adrenocorticotropic Hormone (ACTH) and prostaglandin (PGE2, PGF2α).…”

“…To order to solve the side effects such as crust, purpura, PIH and scarring caused by the traditional laser therapy, the authors devised the combination treatment of Dr. Hoon Hur's Golden Parameter Therapy (GPT) with a high fluence 1064nm Q-switched Nd:YAG laser (Spectra Laser, Lutronic, South Korea) at a oneweek interval with a spot size of 7 mm, a fluence of 2.4 J/cm 2 and a pulse rate of 10 Hz with slowly one pass by a sliding-stacking technique to the Hori's nevus and subsequently Dr. Hoon Hur's Optimal Melanocytic Suicide-2 (OMS-2) Parameter Therapy with a high fluence 1064nm Q-switched Nd:YAG laser (Spectra Laser, Lutronic, South Korea) at a one-week interval with a spot size of 3 mm, a fluence of 5 J/cm 2 and a pulse rate of 10 Hz with a pulse stacking technique for 5 seconds to the Hori's nevus. We believe the combination treatment of Dr. Hoon Hur's Golden Parameter Therapy and Dr. Hoon Hur's Optimal Melanocytic Suicide-2 Parameter Therapy using a high fluence 1064nm Q-switched Nd:YAG laser is a safer and more effective treatment for Hori's nevus than the methods tried so far [13][14][15][16][17]. This combination treatment may destroy dermal melanocytes completely without keratinocyte damage, and the end products of damaged melanocytes will be removed via transepidermal elimination [13][14][15][16][17].…”

“…We believe the combination treatment of Dr. Hoon Hur's Golden Parameter Therapy and Dr. Hoon Hur's Optimal Melanocytic Suicide-2 Parameter Therapy using a high fluence 1064nm Q-switched Nd:YAG laser is a safer and more effective treatment for Hori's nevus than the methods tried so far [13][14][15][16][17]. This combination treatment may destroy dermal melanocytes completely without keratinocyte damage, and the end products of damaged melanocytes will be removed via transepidermal elimination [13][14][15][16][17]. Also the end products, including the dispersed melanosomes and melanins of damaged dermal melanocytes are phagocytized by the macrophages and are removed through the lymphatic system [13][14][15][16][17].…”

“…This combination treatment may destroy dermal melanocytes completely without keratinocyte damage, and the end products of damaged melanocytes will be removed via transepidermal elimination [13][14][15][16][17]. Also the end products, including the dispersed melanosomes and melanins of damaged dermal melanocytes are phagocytized by the macrophages and are removed through the lymphatic system [13][14][15][16][17]. In the previous papers, the authors already reported the therapeutic effects of Dr. Hoon Hur's Golden Parameter Therapy with a high 1064 nm Q-switched Nd:YAG laser and we believe that destroying epidermal melanocytes or dermal melanocytes can be performed with minimal epidermal damage and accelerating apoptotic melanocytic cell death program, and improving various skin diseases such as café au lait spot, partial unilateral lentiginosis, Becker's nevus, Ota's nevus and congenital melanocytic nevus without side effects such as PIH and scarring are also achievable [13][14][15][16][17].…”