The Treatment of North American Blastomycosis with Amphotericin B

Harrell, E. Richard; Curtis, Arthur C.

doi:10.1001/archderm.1957.01550230025004

Cited by 41 publications

(5 citation statements)

References 12 publications

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“…Not long after being first isolated in 1956, amphotericin B was found to be effective for the treatment of blastomycosis. 70 Five large series of patients showed that therapy with a cumulative dose of at least 1 g of amphotericin B deoxycholate resulted in cure without relapse in 77 to 91% of patients. 2,[71][72][73][74] Abernathy showed in 1967 that cumulative doses of 2 g resulted in cure rates up to 97%.…”

Section: Diagnosismentioning

confidence: 99%

Pulmonary Blastomycosis

Bariola

Vyas

2011

Semin Respir Crit Care Med

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Blastomyces dermatitidis is acquired in almost all cases via inhalation, and pulmonary disease is the most frequent clinical manifestation of blastomycosis. Pulmonary disease can range from asymptomatic infection to rapidly severe and fatal disease. Most cases will present as pneumonia, either acute or chronic, or as a lung mass. In rare cases pulmonary blastomycosis is associated with the acute respiratory distress syndrome. Blastomycosis can present as isolated pulmonary disease or along with coexisting extrapulmonary disease that usually will involve the skin, bony structures, genitourinary tract, or central nervous system. Diagnosis is largely based on isolation of the organism via culture or visualization of the organism in clinical specimens. Detection of urinary Blastomyces antigen is a recent addition to diagnostic options. Itraconazole is the drug of choice for most forms of the disease; amphotericin B is reserved for the more severe forms. Newer azoles such as voriconazole and posaconazole have a limited role in the treatment of pulmonary blastomycosis.

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Section: Diagnosismentioning

confidence: 99%

Pulmonary Blastomycosis

Bariola

Vyas

2011

Semin Respir Crit Care Med

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“…As reviewed elsewhere in this issue, 24 many studies, but not all, 42 found outdoor occupations made up a minority of blastomycosis cases. There have been reports of blastomycosis cases in autoworkers based on short case series or case studies, 37,[43][44][45] but no systematic investigation of this connection. Whether auto-related businesses afford opportunities for workplace exposure to Blastomyces, or whether this association simply reflects persons who disproportionately encounter the fungus during home or recreational activities, is unclear.…”

Section: Discussionmentioning

confidence: 99%

Geodemographic Features of Human Blastomycosis in Eastern Wisconsin

Huber¹,

Baumgardner²,

Kram³

et al. 2016

Journal of Patient-Centered Research and Reviews

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“…In contrast, B. dermatitidis rarely involves isolated skeletal muscle. In our review of over 1400 blastomycosis cases published in English (Table 1), which included cases reported before the availability of effective antifungal chemotherapy, 8 eight patients with infection of the psoas muscles and two patients with disseminated disease and unspecified skeletal muscle infection were identified 5–7,9–23 . In all cases with sufficient clinical information to assess the involvement of adjacent bone or soft tissue, psoas muscle abscesses were uniformly associated with vertebral osteomyelitis.…”

Section: Discussionmentioning

confidence: 99%

Classic pyomyositis of the extremities as an unusual manifestation ofBlastomyces dermatitidis: a report of two cases

Lin

Chihara

Smith

et al. 2009

Mycoses

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Pyomyositis is an infection of skeletal muscle that, by definition, arises intramuscularly rather than secondarily from adjacent infection. It is usually associated with bacterial infection, particularly Staphylcococcus aureus. Fungi are rare causes, and Blastomyces dermatitidis has not been reported previously. In this case series, we report two cases of pyomyositis caused by B. dermatitidis. Cases were prospectively identified through routine clinical care at a single academic referral hospital. Two patients with complaints of muscle pain and subacute cough were treated at our hospital in 2007. Both patients were found to have pyomyositis caused by B. dermatitidis- in the quadriceps muscles in one patient, and in the calf muscle in another - by radiological imaging and fungal culture. Both were also diagnosed with pneumonia caused by B. dermatitidis (presumptive in one, confirmed in the other). There was no evidence of infection of adjacent structures, suggesting that the route of infection was likely direct haematogenous seeding of the muscle. A review of the literature confirmed that although B. dermatitidis has been described as causing axial muscle infection secondary to adjacent infection such as vertebral osteomyelitis, our description of isolated muscle involvement (classic pyomyositis) caused by B. dermatitidis, particularly of the extremity muscles, is unique. We conclude that B. dermatitidis is a potential cause of classic pyomyositis.

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The Treatment of North American Blastomycosis with Amphotericin B

Cited by 41 publications

References 12 publications

Pulmonary Blastomycosis

Pulmonary Blastomycosis

Geodemographic Features of Human Blastomycosis in Eastern Wisconsin

Classic pyomyositis of the extremities as an unusual manifestation ofBlastomyces dermatitidis: a report of two cases

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