The Treatment of Mycosis Fungoides with a New Agent, Cyclophosphamide (Cytoxan)

Sézary syndrome: Immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC)

“…With the exception of the lower (400-700 mg weekly) maintenance regimen of Abele and Dobson, 228 in which the main side effects seen in 4 patients treated for 2 to 12 months were alopecia, nausea, and vomiting with no leukopenia or thrombocytopenia, leukopenia 229 has been the doselimiting factor for continuous dosing. The potential for hemorrhagic cystitis with oral dosing and, in young patients, germ cell damage, remain as concerns.…”

Current Problems in Mycosis Fungoides and Sezary Syndrome

“…Nitrogen mustard (87, 88) and cyclophosphamide (Cytoxan®) (89)(90)(91) have been used in relatively large num bers of patients, and good initial respOnse rates have been achieved. Methotrexate (92) also has been widely used, with variable responses.…”

Painting Treatment of Nitrogen Mustard in Mycosis Fungoides

“…More and more pharm aceutical products and treatm ents are tried w ithout any considerable success. In the last decade keen interest was shown in substances inhibiting mitosis and especially in nitrogen m ustard (nm) [1,6,8,12,23,34]. On the basis of the investigations of about 20 years it has been definitely stated th a t the general progress of the disease can not be checked by these substances, only the symptoms of the disease may be tem porarily regressed [10,21,33], the recurrence, however, may appear at any time.…”