The Treatment of Mycosis Fungoides with a New Agent, Cyclophosphamide (Cytoxan)

Treatment of Mycosis Fungoides With Cyclophosphamide and Chlorpromazine

“…Since 1960, cyclophosphamide has been used in the treatment of this disease. Abele and Dobson (1960) treated 4 cases with good results in all. Adam (1963) treated a case in the premycotic stage and found cyclophosphamide effective.…”

Other Chemotherapeutic Agents in Cutaneous T-Cell Lymphoma

“…Although multiple studies have shown that single-agent cyclophosphamide has activity against MF/SS, the benefit is often low. [61][62][63][64][65][66] Abele and Dobson 61 reported 4 cases, mostly with early-stage disease, who showed a response. Van Scott and colleagues 66 subsequently reported 11 more cases, with 5 patients responding to single-agent cyclophosphamide at 50 to 300 mg/d for up to 117 days.…”

Sézary syndrome: Immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC)

“…With the exception of the lower (400-700 mg weekly) maintenance regimen of Abele and Dobson, 228 in which the main side effects seen in 4 patients treated for 2 to 12 months were alopecia, nausea, and vomiting with no leukopenia or thrombocytopenia, leukopenia 229 has been the doselimiting factor for continuous dosing. The potential for hemorrhagic cystitis with oral dosing and, in young patients, germ cell damage, remain as concerns.…”