The treatment of children with unilateral Wilms' tumor.

Bone marrow micrometastases in a patient with localized Wilms' tumor

“…However, due to the low survival rate of tumor cells during the post-intravasation phases, neither the presence of circulating cells nor their arrest within the microcirculation is a guarantee that a metastasis will actually occur. Studies using experimental animal models have demonstrated that radiolabeled tumor cells, al-lymph node involvement but without completely eradicating microscopic residual disease, thus resulting in an inappropriate "downstaging" [38]. The case here reported confirmed the occurrence of marrow micrometastases detectable only before chemotherapy and disappearing afterward.…”

Genomic profiling by whole‐genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse

“…A few studies had previously suggested the importance of the age at diagnosis in the prognosis of WT together with other established factors. Children younger than 24 months at initial diagnosis and small-volume Stage I tumors were found to have a better outcome than older children (Green et al, 1993(Green et al, , 2001Pritchard-Jones et al, 2003). Furthermore, lower frequencies of the putative adverse prognostic markers 1p and 16q LOH have been reported in children younger than 24 months with Stage I tumors weighing less than 550 grams (Grundy et al, 2005).…”

Pre‐ or post‐operative treatment for sWilms tumor? who, what, when, where, how, why—and which

“…Those favoring post-op therapy noted the possibility of wrong diagnoses when treatment was given to patients without a tissue diagnosis. Moreover; that the true stage of the tumor was obscured by the pre-op therapy leading to the need for more ''coverage;'' e.g., with anthracyclines to allow for understaging [7]. Next, it needs to be made clear that the stages assigned by the two groups, although similar in wording, are fundamentally different (Table I).…”