Background: Tenosynovial giant cell tumor (T-GCT) and pigmented villonodular synovitis (PVNS) are interchangeable terms for an uncommon benign proliferation of synovial tissue [1][2][3][4][5][6] . Although neoplastic and inflammatory origins have been hypothesized, the etiology of this condition is unknown. There is controversy regarding surgical treatment, as the open and arthroscopic approaches to synovectomy have shown comparable reported outcomes in the literature [5][6][7] . However, direct comparison of these 2 operative methods is problematic because of selective bias in the existing literature and the lack of any prospective, randomized controlled trials. In the posterior aspect of the knee, arthroscopic synovectomy is technically challenging because of anatomical blind spots when viewing this space from an anterior portal in a trans-notch fashion [10][11][12][13][14][15] . Additionally, incomplete arthroscopic synovectomies increase PVNS recurrence rates, making it imperative to remove the entire lesion 8 . The trans-septal portal (TSP) technique utilizes both posteromedial and posterolateral portals to create an intra-articular portal through the posterior septum that separates the 2 posterior compartments of the knee 10-15 . This portal allows working instruments to be passed back-and-forth across the posterior septum and increases the visualization of both the posterosuperior synovial lining of the condyles and the synovial reflection behind the posterior cruciate ligament, enabling a thorough assessment for arthroscopic PVNS resection [10][11][12][13][14][15][16] . In this video article, we describe a posterior arthroscopic synovectomy with use of a TSP for PVNS within the posterior compartment of the knee. Description: The patient is positioned such that the contralateral leg will not obstruct the ability to work in the posteromedial portal. Diagnostic arthroscopy is performed through standard anteromedial and anterolateral portals. Next, with visualization from the anterolateral portal and the knee in 90°of Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSEST/A365).