2022
DOI: 10.3390/biomedicines10081816
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Abstract: MicroRNAs (miRNAs) are small, non-coding RNAs that are essential for the regulation of post-transcriptional gene expression during tissue development and differentiation. They are involved in the regulation of manifold metabolic and hormonal processes and, within the female reproductive tract, in oocyte maturation and folliculogenesis. Altered miRNA levels have been observed in oncological and inflammatory diseases, diabetes or polycystic ovary syndrome (PCOS). Therefore, miRNAs are proving to be promising pot… Show more

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Cited by 17 publications
(6 citation statements)
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“…Although PCOS is a common gynaecological disease in women [21] the mechanisms involved in the aetiology and pathology of PCOS remain elusive. Altered gene expression may play an essential role in PCOS initiation and progression [22]. The DHEA-stimulated rat model presents ovarian, endocrine, and metabolic features that are similar to those of human PCOS, such as polycystic ovaries, excessive androgen, and glucose intolerance [23]; therefore, it is widely used in PCOS studies [24][25][26].…”
Section: Discussionmentioning
confidence: 99%
“…Although PCOS is a common gynaecological disease in women [21] the mechanisms involved in the aetiology and pathology of PCOS remain elusive. Altered gene expression may play an essential role in PCOS initiation and progression [22]. The DHEA-stimulated rat model presents ovarian, endocrine, and metabolic features that are similar to those of human PCOS, such as polycystic ovaries, excessive androgen, and glucose intolerance [23]; therefore, it is widely used in PCOS studies [24][25][26].…”
Section: Discussionmentioning
confidence: 99%
“…Evidence is growing about the therapeutic potential of miRNAs in the management of numerous diseases, including PCOS [ 125 , 126 ]. The post-transcriptional regulation of gene expression is carried out by miRNAs, which are small non-coding RNAs with a length of about 22 nucleotides.…”
Section: Emerging Therapeuticsmentioning
confidence: 99%
“…Certain miRNAs might serve as novel biomarkers for a PCOS-related aberrant metabolism, decreased oocyte quality, and low endometrial receptivity [ 126 ]. For instance, by controlling steroidogenesis, inducing proliferation, and apoptosis, miR-182 and miR-15a are crucial for the physiology of GCs in the ovaries; however, their levels were noticeably low in the ovarian cells of a PCOS rat model [ 136 ].…”
Section: Emerging Therapeuticsmentioning
confidence: 99%
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“…15 C-reactive protein (CRP), IL-18, TNF-α, IL-6, white blood cell count (WBC), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1α (MIP-1α) are all noticeably elevated, according to a prior review. 16 Numerous studies 17,18 have demonstrated that inflammation is linked to PCOS progression and is favorably correlated with markers such PLR, NLR, and SII. The severity of 19 PLR and NLR may be employed as possible blood indicators for endometriosis, according to a number of studies.…”
Section: Discussionmentioning
confidence: 99%