The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal

Seim, Inge; Ma, Siming; Zhou, Xuming; Gerashchenko, Maxim V.; Lee, Sang-goo; Suydam, Robert; George, John C.; Bickham, John W.; Gladyshev, Vadim N.

doi:10.18632/aging.100699

Cited by 56 publications

(40 citation statements)

References 104 publications

(123 reference statements)

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“…The DNA replication processivity factor PCNA and the amino acid sensor and mTORC1 activator LAMTOR1 also underwent both gene duplication and unique amino acid changes. Transcriptional analysis suggested differential expression of genes involved in DNA replication in the bowhead whale liver compared to other mammals (Seim et al, 2014). Interestingly, the UCP1 gene (coding for uncoupling protein 1), which has several unique amino acid changes in the naked mole rat (Kim et al, 2011), also has a premature stop codon in C-terminal region in the bowhead whale (Keane et al, 2015).…”

Section: Bowhead Whalementioning

confidence: 99%

“…The past few years have seen the publication of the genomes of several species known for their remarkable lifespan or cancer resistance (Gorbunova et al, 2014) (Figure 2B): naked mole rat (Kim et al, 2011), blind mole rat ( Spalax galili ) (Fang et al, 2014a), African elephant (Abegglen et al, 2015), Brandt’s bat (Seim et al, 2013), black flying fox ( Pteropus alecto ) and David’s Myotis ( Myotis davidii ) (Zhang et al, 2013), bowhead whale (Keane et al, 2015; Seim et al, 2014) and Minke whale ( Balaenoptera acutorostrata ) (Yim et al, 2014). On the other end of the longevity spectrum, the genome of the African turquoise killifish ( Nothobranchius furzeri ), which is a particularly short-lived species (4–6 months in captivity), was also published recently by two groups (Reichwald et al, 2015; Valenzano et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Molecular signatures of longevity: Insights from cross-species comparative studies

Gladyshev

2017

Seminars in Cell & Developmental Biology

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Much of the current research on longevity focuses on the aging process within a single species. Several molecular players (e.g. IGF1 and MTOR), pharmacological compounds (e.g. rapamycin and metformin), and dietary approaches (e.g. calorie restriction and methionine restriction) have been shown to be important in regulating and modestly extending lifespan in model organisms. On the other hand, natural lifespan varies much more significantly across species. Within mammals alone, maximum lifespan differs more than 100 fold, but the underlying regulatory mechanisms remain poorly understood. Recent comparative studies are beginning to shed light on the molecular signatures associated with exceptional longevity. These include genome sequencing of microbats, naked mole rat, blind mole rat, bowhead whale and African turquoise killifish, and comparative analyses of gene expression, metabolites, lipids and ions across multiple mammalian species. Together, they point towards several putative strategies for lifespan regulation and cancer resistance, as well as the pathways and metabolites associated with longevity variation. In particular, longevity may be achieved by both lineage-specific adaptations and common mechanisms that apply across the species. Comparing the resulting cross-species molecular signatures with the within-species lifespan extension strategies will improve our understanding of mechanisms of longevity control and provide a starting point for novel and effective interventions.

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Section: Bowhead Whalementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular signatures of longevity: Insights from cross-species comparative studies

Gladyshev

2017

Seminars in Cell & Developmental Biology

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“…Examples include the amino acid changes in Uncoupling Protein 1 (UCP1) and production of high-molecular-mass hyaluronan in the naked mole rat (Kim et al, 2011; Tian et al, 2013); unique sequence changes in IGF1 and GH receptors in Brandt’s bat (Seim et al, 2013); gene gain and loss associated with DNA repair, cell-cycle regulation, and cancer, as well as alteration in insulin signaling in the bowhead whale (Keane et al, 2015; Seim et al, 2014); and duplication of the p53 gene in elephants (Abegglen et al, 2015). Again, it is important to ascertain whether these mechanisms are unique characteristics of specific exceptionally long-lived species, or whether they can also help account for the general lifespan variation (Martin, 1988; Partridge and Gems, 2002).…”

Section: Introductionmentioning

confidence: 99%

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Upneja

Galecki

et al. 2016

eLife

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Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell culture conditions. We developed a pipeline for obtaining species-specific ortholog sequences, profiled gene expression by RNA-seq and small molecules by metabolite profiling, and identified genes and metabolites correlating with species longevity. Cells from longer lived species up-regulated genes involved in DNA repair and glucose metabolism, down-regulated proteolysis and protein transport, and showed high levels of amino acids but low levels of lysophosphatidylcholine and lysophosphatidylethanolamine. The amino acid patterns were recapitulated by further analyses of primate and bird fibroblasts. The study suggests that fibroblast profiling captures differences in longevity across mammals at the level of global gene expression and metabolite levels and reveals pathways that define these differences.DOI: http://dx.doi.org/10.7554/eLife.19130.001

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“…Bowhead whales (Balaena mysticetus) are well adapted to extreme arctic and sub-arctic conditions (Niebauer and Schell, 1993;Seim et al, 2014). For much of their year there is little to no sunlight.…”

Section: Introductionmentioning

confidence: 99%

A year in the acoustic world of bowhead whales in the Bering, Chukchi and Beaufort seas

Clark

Berchok

Blackwell³

et al. 2015

Progress in Oceanography

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The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal

Cited by 56 publications

References 104 publications

Molecular signatures of longevity: Insights from cross-species comparative studies

Molecular signatures of longevity: Insights from cross-species comparative studies

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

A year in the acoustic world of bowhead whales in the Bering, Chukchi and Beaufort seas

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