The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells

Mu, Jian; Liu, Tianrun; Jiang, Lin; Wu, Xiangsong; Yang, Cao; Li, Maolan; Dong, Qian; Liu, Yingbin; Xu, Haineng

doi:10.7150/jca.13548

Cited by 92 publications

(49 citation statements)

References 31 publications

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“…Baicalein is one of major flavonoids found in Scutellaria baicalensis . Previous studies have indicated that baicalein inhibits cell growth and metastasis and increases the sensitization of chemotherapeutic drugs via various pathways . However, few studies have reported changes in miRNA expression.…”

Section: Discussionmentioning

confidence: 99%

Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR‐424‐3p and targeting PTEN/PI3K/Akt pathway

Wang

Chen

et al. 2018

J Cellular Molecular Medi

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Lung cancer is the leading cause of death in individuals with malignant disease. Non‐small‐cell lung cancer (NSCLC) is the most common type of lung cancer, and chemotherapy drugs such as cisplatin are the most widely used treatment for this disease. Baicalein is a purified flavonoid compound that has been reported to inhibit cancer cell growth and metastasis and increase sensitization to chemotherapeutic drugs via different pathways. Therefore, we assessed the effects of baicalein on the proliferation, apoptosis and cisplatin sensitivity in the NSCLC A549 and H460 cell lines and determined the pathways through which baicalein exerts its effects. Baicalein was slightly toxic to normal human bronchial NHBE cells but inhibited growth, induced apoptosis and increased cisplatin sensitivity in A549 and H460 cells. Baicalein down‐regulated miR‐424‐3p, up‐regulated PTEN expression and down‐regulated expression of PI3K and p‐Akt in A549 and H460 cells. Dual‐luciferase reporter assay demonstrated that PTEN is a target gene of miR‐424‐3p, and overexpression of miR‐424‐3p or silencing of PTEN partially attenuated the effects of baicalein on A549 and H460 cells. Taken together, we concluded that baicalein inhibits cell growth and increases cisplatin sensitivity to A549 and H460 cells via down‐regulation of miR‐424‐3p and targeting the PTEN/PI3K/Akt pathway.

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Section: Discussionmentioning

confidence: 99%

Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR‐424‐3p and targeting PTEN/PI3K/Akt pathway

Wang

Chen

et al. 2018

J Cellular Molecular Medi

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“…A recent study reported that baicalein induced cell cycle arrest at the S phase of division and promoted apoptosis in SGC-7901 gastric cancer cell lines via downregulation and upregulation of Bcl-2 and Bax levels, respectively. An in vivo study also revealed that baicalein excellently inhibited tumor growth in subcutaneous xenograft models [42]. Baicalein treatment inhibited the migration and invasion of GC cells in Transwell and wound-healing assays.…”

Section: Baicalein and Gastric Cancermentioning

confidence: 99%

The Fascinating Effects of Baicalein on Cancer: A Review

Liu

Dong

Gao

et al. 2016

IJMS

189

133

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Cancer is one of the leading causes of death worldwide and a major global health problem. In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased for a variety of reasons. Despite treatment options, there are serious side effects associated with chemotherapy drugs and multiple forms of drug resistance that significantly reduce their effects. There is an accumulating amount of evidence on the pharmacological activities of baicalein (e.g., anti-inflammatory, antioxidant, antiviral, and antitumor effects). Furthermore, there has been great progress in elucidating the target mechanisms and signaling pathways of baicalein’s anti-cancer potential. The anti-tumor functions of baicalein are mainly due to its capacities to inhibit complexes of cyclins to regulate the cell cycle, to scavenge oxidative radicals, to attenuate mitogen activated protein kinase (MAPK), protein kinase B (Akt) or mammalian target of rapamycin (mTOR) activities, to induce apoptosis by activating caspase-9/-3 and to inhibit tumorinvasion and metastasis by reducing the expression of matrix metalloproteinase-2/-9 (MMP-2/-9). In this review, we focused on the relevant biological mechanisms of baicalein involved in inhibiting various cancers, such as bladder cancer, breast cancer, and ovarian cancer. Moreover, we also summarized the specific mechanisms by which baicalein inhibited the growth of various tumors in vivo. Taken together, baicalein may be developed as a potential, novel anticancer drug to treat tumors.

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“…Baicalein has been shown to inhibit cell growth and induce apoptosis in many human cancer cells including melanoma cancer (Lee et al ., 2005; Kim et al ., 2012; Li et al ., 2013; Wang et al ., 2014; Liu-Smith and Meyskens, 2016; Mu et al ., 2016). Although it has also been reported that baicalein reduces prostate, lung, breast, and liver cancer as well as osteosarcoma cell metastasis in vitro and/or in vivo (Wang et al ., 2010; Chen et al ., 2013; Zhang et al ., 2013; Gong et al ., 2014; Guo et al ., 2015), to the best of our knowledge, no studies have investigated the antimetastatic effect of baicalein in melanoma cells.…”

Section: Introductionmentioning

confidence: 99%

Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway

Choi

Cho

Jeong

et al. 2016

Biomol Ther (Seoul)

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Baicalein, a natural flavonoid obtained from the rhizome of Scutellaria baicalensis Georgi, has been reported to have anticancer activities in several human cancer cell lines. However, its antimetastatic effects and associated mechanisms in melanoma cells have not been extensively studied. The current study examined the effects of baicalein on cell motility and anti-invasive activity using mouse melanoma B16F10 cells. Within the noncytotoxic concentration range, baicalein significantly inhibited the cell motility and invasiveness of B16F10 cells in a concentration-dependent manner. Baicalein also reduced the activity and expression of matrix metalloproteinase (MMP)-2 and -9; however, the levels of tissue inhibitor of metalloproteinase-1 and -2 were concomitantly increased. The inhibitory effects of baicalein on cell motility and invasiveness were found to be associated with its tightening of tight junction (TJ), which was demonstrated by an increase in transepithelial electrical resistance and downregulation of the claudin family of proteins. Additionally, treatment with baicalein markedly reduced the expression levels of lipopolysaccharide-induced phosphorylated Akt and the invasive activity in B16F10 cells. Taken together, these results suggest that baicalein inhibits B16F10 melanoma cell migration and invasion by reducing the expression of MMPs and tightening TJ through the suppression of claudin expression, possibly in association with a suppression of the phosphoinositide 3-kinase/Akt signaling pathway.

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The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells

Cited by 92 publications

References 31 publications

Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR‐424‐3p and targeting PTEN/PI3K/Akt pathway

Baicalein inhibits cell growth and increases cisplatin sensitivity of A549 and H460 cells via miR‐424‐3p and targeting PTEN/PI3K/Akt pathway

The Fascinating Effects of Baicalein on Cancer: A Review

Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway

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