The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain ofCaenorhabditis elegans

Güven, Kemal; Power, Rowena S.; Avramides, Sophia; Allender, Rebecca; Pomerai, David I. de

doi:10.1002/(sici)1099-0461(1999)13:6<324::aid-jbt6>3.0.co;2-q

Cited by 33 publications

(38 citation statements)

References 39 publications

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“…The underlying strategy created by Donkin and Dusenbery [315][316][317][318][319][320][321][322][323][324][325][326][327][328] has prompted to an institutionalized soil toxicological testing technique received in 2001 by the American Society for Testing and Materials and as of late the International Standards Organization in Europe (ISO 2007). The underlying extraction technique has been enhanced using transgenic strains of nematodes which takes into consideration GFP-named worms to be utilized that recognizes the worms being tried in soils from the vast quantities of indigenous species that are comparable in size and appearance.…”

Section: Strains Investigated Observations Referencesmentioning

confidence: 99%

Discovering Capacity in Novel Targets: C. Elegans as a Model Life Form in Toxicological Research

Ac¹,

Costa²,

Tec³

et al. 2017

J Clinic Toxicol

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The nematode Caenorhabditis elegans has risen as a critical creature show in different fields including neurobiology, formative science, and hereditary qualities. Qualities of this creature demonstrate that have added to its prosperity incorporate its hereditary manipulability, invariant and completely depicted formative program, all around portrayed genome, simplicity of support, short and productive life cycle, and little body estimate. These same elements have prompted to an expanding utilization of C. elegans in toxicology, both for robotic reviews and highthroughput screening approaches. We depict a portion of the exploration that has been completed in the territories of neurotoxicology, hereditary toxicology, and ecological toxicology, and additionally high-throughput tries different things with C. elegans including all inclusive screening for sub-atomic focuses of harmfulness and fast danger evaluation for new chemicals. We contend for an expanded part for C. elegans in supplementing other model frameworks in toxicological research.

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Section: Strains Investigated Observations Referencesmentioning

confidence: 99%

Discovering Capacity in Novel Targets: C. Elegans as a Model Life Form in Toxicological Research

Ac¹,

Costa²,

Tec³

et al. 2017

J Clinic Toxicol

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show abstract

“…When nematodes are exposed to stresses (such as organic toxins, heat or metal ions) the expression of such proteins is enhanced (Kammenga et al, 1998;Neher, 2001). The proteins concerned also have the potential to function as biomarkers during eco-toxicological evaluations of soils (Guven et al, 1994(Guven et al, , 1999Kammenga et al, 2000).…”

Section: Nematode Communities As Bio-indicators Of Soil Healthmentioning

confidence: 99%

Options for Soil Health Measurement in Vineyards and Deciduous Fruit Orchards, with Special Reference to Nematodes

Kapp

Storey²,

Malan

2016

SAJEV

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Soil is a non-renewable resource and supports all land-based forms of life. The sustainable production of crops is becoming progressively more critical as human populations increase and viable agricultural land decreases. Soil health plays an indispensable part in the sustainability of soil as a resource for future generations. For this very reason it is important to have suitable tools to measure the improvement or deterioration of soil health in vineyards and orchards. In this review, the use of different bio-indicators to indicate soil health will be discussed, with special emphasis on the use of nematode population structure and function as indicators of soil health. The use of nematodes as a bio-indicator of soil health can play a crucial role in the establishment of future sustainable production of grapes and fruit in the Western Cape. This paper provides a comprehensive review of soil health, the use of different biological indicators, and the potential of nematodes as suitable indicators thereof, aimed at vineyards and deciduous fruit orchards.

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“…We have previously shown [11] that PC72 responds strongly (in terms of b-galactosidase induction) to concentrations of Mancozeb below those recommended for field application (15 g L ‫1מ‬ ), although the related fungicide Maneb has much less effect. Both agents are dithiocarbamates containing chelated metals (Mn ‫ם‬ Zn in Mancozeb.…”

Section: Introductionmentioning

confidence: 96%

“…Our laboratory has focussed on the use of transgenic C. elegans strains carrying stress-inducible reporter genes (such as lacZ, encoding b-galactosidase) under the control of heat-shock promoters (such as hsp16). Such strains show stressor-inducible reporter expression in both aquatic [10] and soil [5] media, and are sensitive not only to toxic metal ions [10], but also to a variety of pesticides [11], anti-surface antibodies [12], and lowintensity microwave radiation [13]. Despite their relative insensitivity to single metal stressors, these strains are capable of responding to mixtures of metals at environmentally realistic concentrations [14].…”

Section: Introductionmentioning

confidence: 99%

“…What has been lacking until recently is a comparison of different endpoints for the same test species using the same stressor and exposure conditions. This gap we now remedy, using C. elegans strain PC72 exposed to the dithiocarbamate fungicide, Mancozeb, and its metabolite, ethylenethiourea [11]; the endpoints compared include heat-shock reporter induction, mortality, growth, and two-dimensional protein profiles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toxicity of the dithiocarbamate fungicide Mancozeb to the nontarget soil nematode,Caenorhabditis elegans

Easton

Güven

Pomerai

2001

J. Biochem. Mol. Toxicol.

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The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain ofCaenorhabditis elegans

Cited by 33 publications

References 39 publications

Discovering Capacity in Novel Targets: C. Elegans as a Model Life Form in Toxicological Research

Discovering Capacity in Novel Targets: C. Elegans as a Model Life Form in Toxicological Research

Options for Soil Health Measurement in Vineyards and Deciduous Fruit Orchards, with Special Reference to Nematodes

Toxicity of the dithiocarbamate fungicide Mancozeb to the nontarget soil nematode,Caenorhabditis elegans

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