2018
DOI: 10.1007/s11010-018-3288-x
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Abstract: The human amylin is a pancreatic peptide hormone found in hyperhormonemic state along with insulin in subclinical diabetes. Amylin has been associated with the pathology of type 2 diabetes, particularly due to its ability to assembly into toxic oligomers and amyloid specimens. On the other hand, some variants such as murine amylin has been described as non-amyloidogenic, either in vitro or in vivo. Recent data have demonstrated the amyloid propensity of murine amylin and the therapeutic analogue pramlintide, s… Show more

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Cited by 7 publications
(10 citation statements)
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References 31 publications
(50 reference statements)
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“…4 ), which is selective for oligomeric murine amylin and not responsive to non-agglomerated amylin ( Fig. S11 ), in good agreement with previous results showing responsiveness of the OLIM to toxic oligomeric murine amylin material in non-transgenic mouse pancreas [41]. We have detected expressive responsiveness of the OLIM in zinc-restriction dietary intervention group ( Fig.…”
Section: Resultssupporting
confidence: 90%
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“…4 ), which is selective for oligomeric murine amylin and not responsive to non-agglomerated amylin ( Fig. S11 ), in good agreement with previous results showing responsiveness of the OLIM to toxic oligomeric murine amylin material in non-transgenic mouse pancreas [41]. We have detected expressive responsiveness of the OLIM in zinc-restriction dietary intervention group ( Fig.…”
Section: Resultssupporting
confidence: 90%
“…These limitation stimulated the use of transgenic rodents [6870]. We have previously reported the in vitro amyloid nature of murine amylin [38,39], and subsequently the toxic nature of murine amylin oligomers and its presence in pancreatic tissue in natural abundance of wild-type mice [41]. The techniques used along the years for identification of oligomeric and fibers forms has been demonstrated to have certain limitations [39,71].…”
Section: Discussionmentioning
confidence: 99%
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“…The more common lab model is murine (mouse and rat), known for the alleged lack of responsiveness for amyloid formation regardless of the nature of the amyloid polypeptide, although recently demonstrated the oligomer/amyloid phenomena in vitro/ in vivo. 134,135,357,358 Thus, dietary intervention (restriction > repletion) should prove of limited interpretation under the current analytical perspective. Typically, transgenic mice models are used, expressing high amounts of the human-related peptide (amylin, Aβ, α-syn, etc.)…”
Section: The In Vivo Allometric Argumentmentioning
confidence: 99%
“…Testing the hypothesis for amyloid proteins as nutrient sensors could be tricky. The more common lab model is murine (mouse and rat), known for the alleged lack of responsiveness for amyloid formation regardless of the nature of the amyloid polypeptide, although recently demonstrated the oligomer/amyloid phenomena in vitro/in vivo 134,135,357,358 . Thus, dietary intervention (restriction > repletion) should prove of limited interpretation under the current analytical perspective.…”
Section: Testing the Hypothesismentioning
confidence: 99%