The toxic effects of ionic liquids on the activities of acetylcholinesterase and cellulase in earthworms

Luo, Yu; Wang, Sanhu; Yun, Mi-Xia; Li, Xiaoyü; Wang, Jianji; Sun, Zhenjun

doi:10.1016/j.chemosphere.2009.07.026

Cited by 64 publications

(36 citation statements)

References 47 publications

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“…Over the past decade, the toxicity of ILs on aquatic animals (Bernot et al, 2005;Li et al, 2012;Samori et al, 2007;Yu et al, 2009), aquatic plants (Kumar et al, 2010(Kumar et al, , 2011Latala et al, 2005) and aquatic microorganisms (Megaw et al, 2013;Ranke et al, 2004;Ventura et al, 2012;Viboud et al, 2012) has been extensively investigated. Studies have shown that the alkyl chain length of ILs have significant effects on ILs toxic ability (Bernot et al, 2005;Chen et al, 2014;Du et al, 2012;Luo et al, 2009;Radosevic et al, 2013;Ranke et al, 2004;Samori et al, 2007). Among the various aquatic organisms, algae are widely used to monitor water quality and aquatic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus

Liu

Zhang

Chen

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Introductionmentioning

confidence: 99%

Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus

Liu

Zhang

Chen

et al. 2015

Ecotoxicology and Environmental Safety

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“…In Figure 2H, the mixture of ILs mixed at EC 10 could cause a significant effect of 97.7%. This result indicated that EC 10 as an alternative to NOEC was not necessarily conservative in the case of combined exposures. In Figure 2G, the mixture of ILs mixed at 1/11 of individual EC 50 produced 36.5% effect.…”

Section: Mixture Toxicitymentioning

confidence: 75%

“…The CRCs of M1, M2 and M3 mixtures of ILs in the ratios of their EC 50 , EC 10 , and NOEC values respectively on luciferase can be effectively described by the Weibull model (Figure 2A-C). In all cases, the R 2 s were greater than 0.98 and the RMSEs less than 0.04.…”

Section: Mixture Toxicitymentioning

confidence: 99%

“…Although ILs will not cause air pollution because of their negligible vapor pressures, some of them still present a non-negligible solubility in water, thus leading to aquatic environmental risks [9]. Several studies have reported the biological effects of single ILs on the basis of different toxicological test systems such as enzymes (e.g., acetylcholinesterase), bacteria (e.g., Vibrio fischeri), algae (e.g., Selenastrum capricornutum), mammalian cells (e.g., MCF-7 cell), plants (e.g., wheat and cress), invertebrates (e.g., zebra mussel), and vertebrates (e.g., Danio rerio) [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we evaluate the effects of mixtures of imidazolium and pyridimium ILs with S-shaped CRC. Mixture effects of ILs in the ratios of their EC 50 , EC 10 , and NOEC on luciferase were tested based on microplate toxicity analysis. Combined effects were evaluated by comparing the predicted effects by CA, IA, and TSP to the observed effects of these mixtures.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase

Liu

et al. 2014

Molecules

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Abstract:The predicted toxicity of mixtures of imidazolium and pyridinium ionic liquids (ILs) in the ratios of their EC 50 , EC 10 , and NOEC (no observed effect concentration) were compared to the observed toxicity of these mixtures on luciferase. The toxicities of EC 50 ratio mixture can be effectively predicted by two-stage prediction (TSP) method, but were overestimated by the concentration addition (CA) model and underestimated by the independent action (IA) model. The toxicities of EC 10 ratio mixtures can be basically predicted by TSP and CA, but were underestimated by IA. The toxicities of NOEC ratio mixtures can be predicted by TSP and CA in a certain concentration range, but were underestimated by IA. Our results support the use of TSP as a default approach for predicting the combined effect of different types of ILs at the molecular level. In addition, mixtures of ILs mixed at NOEC and EC 10 could cause significant effects of 64.1% and 97.7%, respectively. Therefore, we should pay high attention to the combined effects in mixture risk assessment.

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Toxicity of Ionic Liquids: Eco(cyto)activity as Complicated, but Unavoidable Parameter for Task‐Specific Optimization

2014

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Rapid progress in the field of ionic liquids in recent decades led to the development of many outstanding energy-conversion processes, catalytic systems, synthetic procedures, and important practical applications. Task-specific optimization emerged as a sharpening stone for the fine-tuning of structure of ionic liquids, which resulted in unprecedented efficiency at the molecular level. Ionic-liquid systems showed promising opportunities in the development of green and sustainable technologies; however, the chemical nature of ionic liquids is not intrinsically green. Many ionic liquids were found to be toxic or even highly toxic towards cells and living organisms. In this Review, we show that biological activity and cytotoxicity of ionic liquids dramatically depend on the nature of a biological system. An ionic liquid may be not toxic for particular cells or organisms, but may demonstrate high toxicity towards another target present in the environment. Thus, a careful selection of biological activity data is a must for the correct assessment of chemical technologies involving ionic liquids. In addition to the direct biological activity (immediate response), several indirect effects and aftereffects are of primary importance. The following principal factors were revealed to modulate toxicity of ionic liquids: i) length of an alkyl chain in the cation; ii) degree of functionalization in the side chain of the cation; iii) anion nature; iv) cation nature; and v) mutual influence of anion and cation.

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The toxic effects of ionic liquids on the activities of acetylcholinesterase and cellulase in earthworms

Cited by 64 publications

References 47 publications

Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus

Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus

Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase

Toxicity of Ionic Liquids: Eco(cyto)activity as Complicated, but Unavoidable Parameter for Task‐Specific Optimization

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