Exposure to opioids is largely unavoidable after major surgery because they are routinely used to treat postoperative pain. Nonetheless, continued long-term opioid use has negative health consequences including opioid dependence. 1 Patients and health care professionals are therefore concerned about long-term postoperative opioid use. 2 There are limited data on the risk of previously opioid-naive individuals developing persistent postoperative opioid use. In a 2014 population-based cohort study, we found that 3% of previously opioid-naive patients continued to use opioids 3 months after major elective surgery in Ontario, Canada. 3 Importantly, the risk of persistent opioid use over longer periods after surgery remains unclear. We therefore conducted a follow-up study to measure rates of ongoing opioid use up to 1 year after major surgery.