The tissue distribution of diazinon and the inhibition of blood cholinesterase activities in rats and mice receiving a single intraperitoneal dose of diazinon

Post-Mortem Analysis of Diazinon and its major Metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine, in a Case of Fatal Diazinon Ingestion

“…Therefore, the detection of diazinon and IMHP in postmortem samples was used as a confirmatory test for diazinon exposure. From the toxicokinetic point of view, diazinon is a basic lipophilic compound with a high volume of distribution that may undergo postmortem redistribution [18,19].…”

Post-Mortem Analysis of Diazinon and its major Metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine, in a Case of Fatal Diazinon Ingestion

“…Therefore, the detection of diazinon and IMHP in postmortem samples was used as a confirmatory test for diazinon exposure. From the toxicokinetic point of view, diazinon is a basic lipophilic compound with a high volume of distribution that may undergo postmortem redistribution [18,19].…”

Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour

“…injection) differs from the predicted route of exposure from sheep dipping, which is dermal (Buchanan et al , 2001). Consequently the rate of pesticide absorption in this study will have been more rapid than it would be through occupational exposure (Garfitt, Jones, 2002, Tomokuni, Hasegawa, 1985. Levels of exposure experienced by sheep dippers are difficult to quantify and so we cannot state that the levels of exposure in this study accurately reflect potential occupational exposures.…”

“…An i.p. injection of 40 mg/kg diazinon to adult male wistar rats (340-370g) and 100 mg/kg chlorpyrifos to adult male albino rats (250-350g) (Tomokuni, Hasegawa et al 1985;Sachana, Flaskos et al 2001) is reported to substantially inhibit brain AChE, but we wanted to administer a five day exposure dose which was below the threshold to inhibit AChE. Therefore pilot dose ranging studies were conducted with the second highest dose in each range 100 times less than the previously reported acute AChE inhibiting dose (0, 0.1, 0.4, 1 mg/kg i.p.…”

Organophosphates and carbamates

“…The ADME of OP and CM insecticides in animals have been described (Tomokuni et al, 1985;Gupta, 1994;Wu et al, 1996;Timchalk, 2006Timchalk, , 2010. These insecticides gain entry into the body mainly through oral, dermal or inhalation exposure.…”

Post-Mortem Analysis of Diazinon and its major Metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine, in a Case of Fatal Diazinon Ingestion

“…Therefore, the detection of diazinon and IMHP in postmortem samples was used as a confirmatory test for diazinon exposure. From the toxicokinetic point of view, diazinon is a basic lipophilic compound with a high volume of distribution that may undergo postmortem redistribution [18,19].…”

Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour

“…injection) differs from the predicted route of exposure from sheep dipping, which is dermal (Buchanan et al , 2001). Consequently the rate of pesticide absorption in this study will have been more rapid than it would be through occupational exposure (Garfitt, Jones, 2002, Tomokuni, Hasegawa, 1985. Levels of exposure experienced by sheep dippers are difficult to quantify and so we cannot state that the levels of exposure in this study accurately reflect potential occupational exposures.…”

“…An i.p. injection of 40 mg/kg diazinon to adult male wistar rats (340-370g) and 100 mg/kg chlorpyrifos to adult male albino rats (250-350g) (Tomokuni, Hasegawa et al 1985;Sachana, Flaskos et al 2001) is reported to substantially inhibit brain AChE, but we wanted to administer a five day exposure dose which was below the threshold to inhibit AChE. Therefore pilot dose ranging studies were conducted with the second highest dose in each range 100 times less than the previously reported acute AChE inhibiting dose (0, 0.1, 0.4, 1 mg/kg i.p.…”

Organophosphates and carbamates

“…The ADME of OP and CM insecticides in animals have been described (Tomokuni et al, 1985;Gupta, 1994;Wu et al, 1996;Timchalk, 2006Timchalk, , 2010. These insecticides gain entry into the body mainly through oral, dermal or inhalation exposure.…”

Post-Mortem Analysis of Diazinon and its major Metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine, in a Case of Fatal Diazinon Ingestion

“…Therefore, the detection of diazinon and IMHP in postmortem samples was used as a confirmatory test for diazinon exposure. From the toxicokinetic point of view, diazinon is a basic lipophilic compound with a high volume of distribution that may undergo postmortem redistribution [18,19].…”

Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour

“…injection) differs from the predicted route of exposure from sheep dipping, which is dermal (Buchanan et al , 2001). Consequently the rate of pesticide absorption in this study will have been more rapid than it would be through occupational exposure (Garfitt, Jones, 2002, Tomokuni, Hasegawa, 1985. Levels of exposure experienced by sheep dippers are difficult to quantify and so we cannot state that the levels of exposure in this study accurately reflect potential occupational exposures.…”

“…An i.p. injection of 40 mg/kg diazinon to adult male wistar rats (340-370g) and 100 mg/kg chlorpyrifos to adult male albino rats (250-350g) (Tomokuni, Hasegawa et al 1985;Sachana, Flaskos et al 2001) is reported to substantially inhibit brain AChE, but we wanted to administer a five day exposure dose which was below the threshold to inhibit AChE. Therefore pilot dose ranging studies were conducted with the second highest dose in each range 100 times less than the previously reported acute AChE inhibiting dose (0, 0.1, 0.4, 1 mg/kg i.p.…”

Organophosphates and carbamates

“…The ADME of OP and CM insecticides in animals have been described (Tomokuni et al, 1985;Gupta, 1994;Wu et al, 1996;Timchalk, 2006Timchalk, , 2010. These insecticides gain entry into the body mainly through oral, dermal or inhalation exposure.…”