The times they’re a-changing: Effects of circadian desynchronization on physiology and disease

Golombék, Diego A.; Casiraghi, Leandro P.; Agostino, Patricia V.; Paladino, Natalia; Duhart, José M.; Plano, Santiago Andrés; Chiesa, Juan José

doi:10.1016/j.jphysparis.2013.03.007

Cited by 111 publications

(92 citation statements)

References 182 publications

(210 reference statements)

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“…Exposure to light has a major impact on the behavior, physiology, and pathophysiology of most vertebrates, including mammals (Munch and Bromundt 2012;Golombek et al 2013). The mechanisms that mediate the detection of nonvisual photic cues, however, remain largely unexplored.…”

Section: Discussionmentioning

confidence: 99%

An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function

et al. 2015

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Light affects animal physiology and behavior more than simply through classical visual, image-forming pathways. Nonvisual photoreception regulates numerous biological systems, including circadian entrainment, DNA repair, metabolism, and behavior. However, for the majority of these processes, the photoreceptive molecules involved are unknown. Given the diversity of photophysiological responses, the question arises whether a single photopigment or a greater diversity of proteins within the opsin superfamily detect photic stimuli. Here, a functional genomics approach identified the full complement of photopigments in a highly light-sensitive model vertebrate, the zebrafish (Danio rerio), and characterized their tissue distribution, expression levels, and biochemical properties. The results presented here reveal the presence of 42 distinct genes encoding 10 classical visual photopigments and 32 nonvisual opsins, including 10 novel opsin genes comprising four new pigment classes. Consistent with the presence of light-entrainable circadian oscillators in zebrafish, all adult tissues examined expressed two or more opsins, including several novel opsins. Spectral and electrophysiological analyses of the new opsins demonstrate that they form functional photopigments, each with unique chromophore-binding and wavelength specificities. This study has revealed a remarkable number and diversity of photopigments in zebrafish, the largest number so far discovered for any vertebrate. Found in amphibians, reptiles, birds, and all three mammalian clades, most of these genes are not restricted to teleosts. Therefore, nonvisual light detection is far more complex than initially appreciated, which has significant biological implications in understanding photoreception in vertebrates.

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Section: Discussionmentioning

confidence: 99%

An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function

et al. 2015

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“…Accordingly, most of the mammalian physiology is regulated at some points by the main circadian clock which is located at the hypothalamic suprachiasmatic nuclei (SCN). Circadian coordination is known to be T extremely important for healthy physical and mental function, as many diseases display disruption of circadian rhythms [2,3] . Several studies have reported circadian alterations in cancer patients and tumor-bearing animals [4,5] .…”

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confidence: 99%

Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

et al. 2015

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Circadian clock gene PER3 and its length polymorphism may have a role in oncogenesis as clock genes act as key regulators of cell cycle and DNA repair pathways. The polymorphism may affect the condition of patients who show disrupted circadian rhythm due to tumor development. The aim was to assess the association between PER3 polymorphism and onco-hematological diseases, and analyze whether this variant has an impact on patient's functionality. We conducted a case-control study on 125 patients with onco-hematological diseases and 310 control patients. PER3 allelic variants were detected by using polymerase chain reaction. Sociodemographic data and information on patient's habits and functionality were obtained through questionnaire. Genotypes 4/5 + 5/5 showed an odd ratio (OR) = 1.39, with no statistical significance. However, those genotypes were associated with a two-fold increase in the risk of acute/chronic lymphoblastic/myeloblastic leukemia, taken all together. The occurrence of "changes in humor during last two months" was significantly associated with onco-hematological diseases. "Fatigue on awakening" and "self-reported snore" were associated with cases carrying the 4/5 or 5/5 genotypes. The results suggested that PER3 polymorphism may have a role in the risk of leukemia, and might be a possible marker for individual differences in susceptibility to sleep disruption. This work provides insights for the identification of individuals at high risk of cancer, and those who are more susceptible to circadian disruption, which may decrease the physiological defenses against the tumor. he circadian system regulates metabolism and energy homeostasis on a daily basis in order to maintain vital processes and prepare the organism to respond to predictable/daily environmental conditions [1] . Accordingly, most of the mammalian physiology is regulated at some points by the main circadian clock which is located at the hypothalamic suprachiasmatic nuclei (SCN). Circadian coordination is known to be T

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“…La adaptación del sistema circadiano a señales predecibles del medio ambiente prepara el organismo para optimizar los procesos fisiológicos a las horas más eficientes del día. En el mundo industrializado, fenómenos como la exposición prolongada a la luz y el transporte transatlántico, entre otros, afectan la homeostasis del reloj endógeno, y han sido asociados a un aumento en el riesgo de problemas en la salud humana (2,3). En particular, uno de los procesos más importantes del cuerpo, la proliferación celular, está regulado por el reloj biológico y su alteración puede tener repercusiones directas en la regulación del cáncer.…”

Section: Introductionunclassified

Los ritmos circadianos en cáncer y la cronoterapia

Molina-Rodríguez¹,

Álvarez²

2016

iatreia

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RESUMENLos ritmos circadianos, períodos fisiológicos de 24 horas aproximadamente, coordinan la actividad temporal de la mayoría, si no, de todos los seres vivos del planeta. Uno de los procesos más importantes del cuerpo, la proliferación celular, también está regulado por el reloj biológico cuya alteración puede tener repercusiones directas en el desarrollo del cáncer. El concepto de cronoterapia ha surgido a partir de la evidencia que tanto la proliferación de las células, como los mecanismos responsables de la farmacocinética y la farmacodinamia de los antineoplásicos ocurren a horas específicas del día. En esta revisión se presentan las generalidades del ciclo circadiano y su relación con el ciclo celular y el cáncer. Además, se expone evidencia del uso de la cronoterapia en pacientes con leucemia linfocítica aguda y en estudios clínicos de cáncer de colon, endometrio y ovario con asignación aleatoria. Se concluye que la hora de administración de la quimioterapia debe tener en cuenta los ritmos circadianos de los pacientes. Se enfatiza en la necesidad de hacer estudios clínicos enfocados en la quimioterapia cronomodulada, con el fin de aumentar la tolerancia y efectividad de los medicamentos con los protocolos existentes.

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The times they’re a-changing: Effects of circadian desynchronization on physiology and disease

Cited by 111 publications

References 182 publications

An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function

An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function

Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

Los ritmos circadianos en cáncer y la cronoterapia

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