The time clock system: a new oral dosage form for fast and complete release of drug after a predetermined lag time☆

Pozzi, F.; Furlani, Pia; Gazzaniga, A.; Davis, S.S.; Wilding, Ian R.

doi:10.1016/0168-3659(94)90255-0

Cited by 131 publications

(50 citation statements)

References 17 publications

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“…These systems usually show burst drug release after the lag time, mainly due to the superdisintegrants and highly swellable agents which act upon the dissolution and permeability of the protective coating. TIME-CLOCK™ system, proposed by Pozzi et al (Pozzi et al, 1994) (Leopold, 2001;Verma et al, 2000Verma et al, , 2002. Because of its drug-impermeable enteric coating, the release from each push-pull unit is prevented and delayed until higher pH values.…”

Section: Ph Time and Microbiologically Dependent Systems For Colon Tmentioning

confidence: 99%

Drug Targeting in IBD Treatment – Existing and New Approaches

Goračinova¹,

Dodov²,

Crcarevska³

et al. 2012

Inflammatory Bowel Disease - Advances in Pathogenesis and Management

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Section: Ph Time and Microbiologically Dependent Systems For Colon Tmentioning

confidence: 99%

Drug Targeting in IBD Treatment – Existing and New Approaches

Goračinova¹,

Dodov²,

Crcarevska³

et al. 2012

Inflammatory Bowel Disease - Advances in Pathogenesis and Management

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“…It can be called as "time-programmed delivery system" and different systems have been developed using various techniques and functional polymers or additives (Pozzi et al, 1994;Narisawa et al, 1994;Matsuo et al, 1995). Press coating system is one of the techniques controlling drug release rate and delivering the drug in the gut when it is needed.…”

Section: Current Issues and Challenges Of Multi-layered Tabletsmentioning

confidence: 99%

Multi-Layered Matrix Tablets with Various Tablet Designs and Release Profiles

Choi¹,

Jeong²

2011

Journal of Pharmaceutical Investigation

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− Tablet dosage forms have been preferred over other formulations for the oral drug administration due to their low manufacturing costs and ease of administrations, especially controlled-release applications. Controlled-release tablets are oral dosage forms from which the active pharmaceutical ingredient (API) is released over an intended or extended period of time upon ingestion. This may allow a decrease in the dosing frequency and a reduction in peak plasma concentrations and hence improves patient compliance while reducing the risk of undesirable side effects. Conventional singlelayered matrix tablets have been extensively utilized to deliver APIs into the body. However, these conventional single-layered matrix tablets present suboptimal delivery properties, such as non-linear drug delivery profiles which may cause higher side effects. Recently, a multi-layered technology has been developed to overcome or eliminate the limitations of the singlelayered tablet with more flexibility. This technology can give a good opportunity in formulating new products and help pharmaceutical companies enhancing their life cycle management. In this review, a brief overview on the multi-layered tablets is given focusing on the various tablet designs, manufacturing issues and drug release profiles.

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“…The newest developed drug delivery systems are consistent with biological rhythms and medication delivery is tailored to the peak in the manifestation of the symptoms of the disease. [20,21] Contin ® chronopharmaceutical technology is used in the preparation of matrix sustainedrelease Uniphyl ® /Uniphyllin ® tablets with theophylline. [22] This technology is based on the molecular coordination complexes formed between a cellulose polymer and a non-polar solid aliphatic alcohol optionally substituted with an aliphatic group.…”

Section: Introductionmentioning

confidence: 99%

“…Press-coating technique is the most usable techniques for preparation of time-controlled release systems, because of its indisputable advantages. [27,28] : no need of solvents, protection of hygroscopic, light sensitive, oxygen and acid labile drugs, isolation of incompatible drugs from each other, fast and simple manufacturing. [29,30] Usually press-coated tablets comprise inner core surrounded by one or more outer layers that dissolve or disintegrate slowly to produce lag-time.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Single- And Multi-Stage Extrusion Versus Press-Coating Technique in Formulation of Modified-Release Tablets With Theophylline

Petkova¹

2017

WJPPS

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Theophylline has been used in the treatment of respiratory diseases such as asthma and COPD for more than 80 years. It is still a common reported drug, especially for patients with a pronounced clinical picture due to its easy application and low price. The bronchodilating action of theophylline makes the drug useful in the chronic treatment of bronchial asthma, but its narrow therapeutic concentration range and variable pharmacokinetics make dosing management of the drug difficult, which requires utilization of modified release drug dosage forms. One approach to increase the effectiveness of pharmacotherapy is to administer medications while they are most effective and/or tolerable. The principles of chronotherapy can be applied by designing and characterizing drug delivery systems that synchronize drug release with the rhythm of disease activity.Time-controlled release rate can be achieved in many ways, but press-coating technology and multiple-unit pellet systems (MUPS) are one of the most promising techniques. For the purpose of the present study -development of chronopharmaceutical system for treatment of nocturnal asthma, nine formulations tablets prepared from pellets via single-(E1-1-E3-1), two-(E1-2-E3-2) and three-stage (E1-3-E3-3) extrusion and nine formulations single-(T1-1-T3-1), two-(T1-2-T3-2) and three-layered (T1-3-T3-3) press-coated tablets using different polymer blends were prepared, characterized and compared. Formulations with HPMC release slower than formulations with CMC Na and increasing viscosity grade of HPMC, leads to decreasing in release rate. Moreover, fastest is the release rate from single-extruded pellets and slowest -from three-stage extruded pellets. Comparing method of preparationpress-coating technique gives faster release of API than multi-stage extrusion. Among all formulations, formulations E1-3, E2-3, E3-3 and T2-3 exhibit the desired chronotherapeutical release profile -taken before bedtime they deliver API between midnight and early morning hours when asthma incidents are with higher frequency. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

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The time clock system: a new oral dosage form for fast and complete release of drug after a predetermined lag time☆

Cited by 131 publications

References 17 publications

Drug Targeting in IBD Treatment – Existing and New Approaches

Drug Targeting in IBD Treatment – Existing and New Approaches

Multi-Layered Matrix Tablets with Various Tablet Designs and Release Profiles

Comparison of Single- And Multi-Stage Extrusion Versus Press-Coating Technique in Formulation of Modified-Release Tablets With Theophylline

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