The Thr715Pro Polymorphism of the P-Selectin Gene Is Not Associated With Ischemic Stroke Risk

Abstract

Background and Purpose-A ThrϾPro polymorphism at codon 715 in the coding region of the P-selectin gene has recently been described. Individuals carrying the Pro715 allele were reported to have a reduced risk of myocardial infarction. A possible association of this polymorphism with the risk of ischemic stroke is currently under discussion. Methods-We investigated the prevalence of the 715 ThrϾPro polymorphism in 450 patients aged younger than 60 years with ischemic stroke or transient ischemic attack and in 450 controls without vascular disease matched for age and gender. We also investigated possible interactions of the polymorphism with other vascular risk factors, stroke severity and stroke etiology. Results-The distribution of the two allelic variants of the 715ThrϾPro polymorphism did not differ significantly between patients and control subjects (78% versus 81% for Thr/Thr, 21% versus 18% for Thr/Pro and 1% versus 1% for Pro/Pro in patients and controls, respectively; adjusted odds ratio for carriers of the C allele: 1.0 [0.8 to 1.2; Pϭ0.695]). We found no significant interaction of this polymorphism with vascular risk factors, stroke severity, or stroke etiology. Conclusions-Our study supports results from previous investigation showing that the 715ThrϾPro polymorphism of the P-selectin gene was not associated with a risk or clinical characteristics of ischemic stroke.

Association of the single-nucleotide polymorphism and haplotype of the P-selectin gene with ischemic stroke

“…These findings confirmed the results of Barbaux et al [38]. Recently, several authors have investigation of Thr715Pro P-selectin gene polymorphism and ischemic stroke [14][15][16], they have demonstrated that there was no apparent relationship of the P-selectin Thr715Pro polymorphism with the risk of ischemic stroke. However, in the current study, we found that P-selectin Thr715Pro did not show any polymorphism in either patients or controls.…”

“…In the current study, the frequencies of the -2,123 C, -1,969 G and -1,817 T alleles among the control subjects were 0.338, 0.843 and 0.666, respectively, but the frequencies [19,22]. In addition, the frequencies of the 715 Pro allele among the control subjects in populations of UK, France, Germany and Austria were 0.104, 0.102, 0.139 and 0.102, respectively [16,19,22,23]. However, P-selectin Thr715Pro did not show any polymorphism in either patients or controls in this study, suggesting that the distribution of P-selectin gene frequencies might vary among the different ethnic groups.…”

“…Polymorphism of P-selectin gene Thr715Pro at exon 13 is correlated with P-selectin production or protein expression [12,13]. Recently, a number of polymorphisms in the gene encoding P-selectin have been identified and a relationship between the P-selectin Thr715Pro polymorphism and risk for coronary heart disease and ischemic stroke have been reported [12,[14][15][16]. However, no studies, to date, have examined the association between -2,123 G/C, -1,969 G/A, -1,817 T/C polymorphisms in P-selectin gene and ischemic stroke.…”

Association of PS gene polymorphism and soluble P-selectin levels in atrial fibrillation thromboembolism population in Xinjiang

“…But the frequencies were different from those of Northern Ireland and French populations in an ECTIM study (0.386; 0.470, respectively) [11]. The frequencies of the Pro715 allele among the healthy subjects in Europeans and European-Americans were about 10% [11,14], meanwhile the Pro715 variant allele of P-selectin was found to correlate with lower sPs levels and was reported that plays a protective role of myocardial infarction in European Caucasians [15]. P-selectin polymorphisms at positions À2123C/G, À1969A/G, À1817T/C and Ser290Asn were reported to be in tight linkage disequilibrium with each other in Europeans [16].…”

Frequency distribution of single nucleotide polymorphisms in P-selectin gene in Chinese Tibetan and Han populations

“…The frequencies of the Pro715 allele among the healthy subjects in Europeans and European-Americans were about 10% (Ferrari et al, 2007;Herrmann et al, 1998), meanwhile the Pro715 variant allele of P-selectin was found to correlate with lower sPselectin levels and was reported to have a protective effect from myocardial infarction in European Caucasians (Kee et al, 2000). Among African-Americans, Val599Leu was more strongly associated with a high level of sP-selectin, and T allele frequency (0.54) was much higher than that in European-Americans (0.12).…”