The Thorpe–Ziegler-type reaction of 3-cyanopyridine-2(1H)-thiones with Biginelli 6-bromomethyl-3,4-dihydropyrimidin-2(1H)-ones: cascade assembling of tetra- and pentacyclic heterocyclic scaffolds

Theophyllinylpyrimidine Scaffolds Undergo Intramolecular Cyclization Reactions to Form 1,3‐Diazepines and Imidazopurines

“…Substituent diversity in the 4‐aryl‐substituted pyrimidines was provided by the Biginelli reaction 16. The high reactivity of both precursors, 6‐halogenomethylpyrimidinecarboxylates13,16,17 2 and 8‐halogenotheophyllines14,15,18 1 , towards nucleophiles has already been reported and hence the alkylation reaction was straightforward, providing high yields of the products 3 (74–91 %; Scheme ).…”

Transformations of Di‐ and Tetrahydropyrimidine Derivatives into Condensed Heterocycles with Retention of their Partially Saturated Structure

“…For example, approach, which is based on bromination and a subsequent nucleophilic replacement reaction, is well documented. 6‐Bromo‐ and 6‐dibromomethyl‐3,4‐dihydropyrimidines are a versatile, readily accessible building blocks for the synthesis of furo[3,4‐ d ]pyrimidines , pyrrolo[3,4‐ d ]pyrimidines , pyrimido[4,5‐ d ]pyridazines , thiazolo[3,4‐ c ]pyrimidine , and cyclopenta[d]pyrimidine .…”

Antiproliferative Activity of Some Newly Synthesized Substituted Nicotinamides Candidates Using Pyridine-2(1H) thione Derivatives as Synthon

“… 18 Also, 3-cyano-2-thioxopyridines are of great interest since they have potential synthetic and biological abilities. 19 …”