The thiol-disulfide balance and the nitric oxide system in the brain tissue of rats subjected to experimental acute impairment of cerebral blood flow: The therapeutic effects of nootropic drugs

Бєленічев, Ігор Федорович; Горбачева, С. В.; Demchenko, A. V.; Bukhtiyarova, N. V.

doi:10.1134/s181971241401005x

Cited by 20 publications

(35 citation statements)

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“…Increased expression of the genes encoding heat shock proteins are regulated by transcription step. Heat shock proteins are called stress proteins, as increased expression of the corresponding genes is often observed in response to stress [3][4][5][6][7][8][9][10] . Their active participation in the most important processes of functioning cells suggests that these proteins play a key regulatory role in providing repair and degradation, and "failure" in the functioning of the "protein machine" -one of the causes of dysfunction and damage of organs and tissues.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Modulation of Heat Shock Protein 70 (HSP70)—Dependent Mechanisms of Endogenous Neuroprotection in Conditions of Prenatal Chronic Alcoholism by Cerebrocurin and Tiocetam

Бєленічев

Sokolik

Bukhtiarova

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Objective:One of the primary reactions of the genome in response to stress is different genesis induction of heat shock proteins -HSP. The purpose of this study was to investigate the concentration of heat shock protein (HSP70) and hypoxia-inducible factor (HIF-1) in the brain of rats undergoing chronic prenatal alcoholism in different periods of ischemia and define the role of these proteins in the implementation of neuroprotective effect of Cerebrocurin and Tiocetam.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Modulation of Heat Shock Protein 70 (HSP70)—Dependent Mechanisms of Endogenous Neuroprotection in Conditions of Prenatal Chronic Alcoholism by Cerebrocurin and Tiocetam

Бєленічев

Sokolik

Bukhtiarova

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…When neurodegeneration, including EAE enhanced expression of proinflammatory cytokines (IL-1, TNF-α, HIF-1) and the factors responsible for the transcription NF-κB, AP-1, JNK, which indirectly, in particular through activation of iNOS, further enhancing the formation of cytotoxic derivatives NO, leading to increased molecular reactions of mitochondrial dysfunction and neuroapoptosis. Strengthening the neuroprotective effect of co-administration of methylprednisolone with tserekson can be explained through the prism of NO-dependent mechanisms of neuroapoptosis and mitochondrial dysfunction [1,18].…”

Section: Results and Its Discussionmentioning

confidence: 99%

Pharmacological analysis of neuroprotective action of methylprednisolone with citicoline in conditions of experimental allergic encephalomyelitis

Nefedov¹,

Mamchur²,

Abramov³

et al. 2016

bmgt

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The paper is devoted to studying the neuroprotective effects of the integrated use of methylprednisolone with citicoline on the processes of energy providing of the mitochondria of neurons of the cerebral cortex and histomorphometric indices in experimental allergic encephalomyelitis. Cooperative administration of the drugs has a significant effect on the mitochondrial dysfunction (reduction in speed of opening of mitochondrial pores, increasing the charge of the inner membrane) and energy metabolism of the brain (increased levels of ATP and ADP, reduced lactate, increase pyruvate and isocitrate). The combined use of methylprednisolone with citicoline limits unproductive activity of anaerobic glycolysis and increases the aerobic reaction.

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“…Despite significant advances in the prevention and management of acute cerebrovascular accident (CVA), the issue continues to be of extreme medical and social importance [2,10]. Stroke is the second leading cause of death and the leading cause of disability among the residents of Ukraine, creating a serious burden for the healthcare system, the economy and society as a whole [2].…”

Section: Abstract: Selenium Derivatives Hsp70 Dependent Mechanisms Neuroprotection Acute Cerebrovascular Accidentmentioning

confidence: 99%

Modulation of HSP70-dependent mechanisms of endogenous neuroprotection with selenium derivatives under conditions of ischemic-type acute cerebrovascular accident modeling

Бєленічев

Горчакова

Bukhtiyarova

et al. 2020

PPS

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The influence of selenium derivatives selenoline, cysteine selenate, and methionine selenate on the main indicators of HSP70-dependent mechanisms of endogenous neuroprotection under conditions of acute cerebrovascular accident (CVA) modeling has been investigated, and pathogenetic substantiation of prospects for their further study as potential neuroprotectors has been given. The experiments have been performed on white Wistar rats by bilateral irreversible ligation of the common carotid artery. Cysteine selenite and methionine selenite at a dose of 30 μg/kg, and selenoline at a dose of 50 μg/kg were introduced intraperitoneally to the experimental animals once-daily for 4 days. Every day for 4 days, the severity of neurological reactions was assessed in points on a stroke-index scale, and the mortality rate in animals was recorded. In the process of biochemical studies of brain tissue, the state of mRNA expression, HSP70 level, hypoxia-induced factors (HIF) -HIF1α and HIF-3α were evaluated using the method of polymerase chain reaction (PCR) with realtime reverse transcription. While false-operated animals developed mild neurological disorders, the control group developed bilateral ptosis, circling movements, paresis and paralysis of the limbs. On the 4th day the mean score on Stroke-index P. McGraw neurological deficit assessment scale was 16.7 ± 0.52, and 40 % of animals survived. In the cytosol and mitochondria of brain tissues, a decrease in HSP70 was detected by 47% and 59%, respectively. The administration of selenite cysteine, selenite methionine and selenoline contributed to the normalization of this indicator, to a greater extent under the action of selenite cysteine. In the control group there was a decrease in HSP70 mRNA expression. After administration of all the studied compounds, a tendency to increase the expression of HSP70 mRNA was observed compared to the controls. Under conditions of cerebral circulation insufficiency ACCI, in brain tissue, a decrease in the synthesis of HIF-1α at the

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The thiol-disulfide balance and the nitric oxide system in the brain tissue of rats subjected to experimental acute impairment of cerebral blood flow: The therapeutic effects of nootropic drugs

Cited by 20 publications

References 0 publications

Pharmacological Modulation of Heat Shock Protein 70 (HSP70)—Dependent Mechanisms of Endogenous Neuroprotection in Conditions of Prenatal Chronic Alcoholism by Cerebrocurin and Tiocetam

Pharmacological Modulation of Heat Shock Protein 70 (HSP70)—Dependent Mechanisms of Endogenous Neuroprotection in Conditions of Prenatal Chronic Alcoholism by Cerebrocurin and Tiocetam

Pharmacological analysis of neuroprotective action of methylprednisolone with citicoline in conditions of experimental allergic encephalomyelitis

Modulation of HSP70-dependent mechanisms of endogenous neuroprotection with selenium derivatives under conditions of ischemic-type acute cerebrovascular accident modeling

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