2019
DOI: 10.1007/s10120-019-00952-w
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Abstract: Metformin is a biguanide molecule used since 1957 to treat type 2 diabetes patients. In addition to its hypoglycemic effects, epidemiological studies have shown that metformin can be associated with a decrease in cancer development risk in diabetic populations. Thus, since 2005 this molecule is largely studied for its antitumoural properties in different types of cancer. The potential antitumoural effect of metformin in gastric cancer has been poorly studied. Here, we detailed the different described mechanism… Show more

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Cited by 20 publications
(13 citation statements)
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“…Treatment strategies of GC include surgery, radiation, therapy, chemoradiation, chemotherapy, and targeted therapy. Some research demonstrated that metformin might also constitute a potential treatment for several types of cancer including GC [35][36][37]. Other potential strategies for the advanced GC include the decrease of the pro-angiogenic ligands levels and the expression of their receptors, the increase of the angiogenic inhibitors levels, as well as directly targeting the inner walls of the ECs [38].…”
Section: Introductionmentioning
confidence: 99%
“…Treatment strategies of GC include surgery, radiation, therapy, chemoradiation, chemotherapy, and targeted therapy. Some research demonstrated that metformin might also constitute a potential treatment for several types of cancer including GC [35][36][37]. Other potential strategies for the advanced GC include the decrease of the pro-angiogenic ligands levels and the expression of their receptors, the increase of the angiogenic inhibitors levels, as well as directly targeting the inner walls of the ECs [38].…”
Section: Introductionmentioning
confidence: 99%
“…The proposed uses of metformin go far beyond the first line intervention in T2D. Metformin is touted as a promising treatment for obesity by inducing weight loss (54), and as a drug for cardiovascular disease (55), cancer (56), and life extension (57,58). Our ongoing laboratory experiments suggest the potential application of DEA for these indications.…”
Section: Discussionmentioning
confidence: 99%
“…78 Indirect effects of metformin include the modulation of (1) the interaction between GC cells and their microenvironment and (2) gut microbiota. 80 Co-culturing GC cells with metformin-pretreated gastric tumor-associated fibroblasts was observed to reduced GC cell proliferation. 81 In addition, in-vivo and in-vitro experiments have demonstrated antibiotic properties of metformin in inhibiting H. pylori, in a dose-dependent manner.…”
Section: Metformin In Reducing Gc Development 1 Anti-tumorigenic Mechanisms Of Metformin On Gc Developmentmentioning
confidence: 96%